Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation

Rhodopsin signalling is triggered by the light-induced isomerization of its 11-cisretinal chromophore. Here, the authors use NMR spectroscopy to define retinal orientation and interactions in the active metarhodopsin II intermediate, proposing a two-stage mechanism for rhodopsin activation.

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Autores principales:	Naoki Kimata, Andreyah Pope, Markus Eilers, Chikwado A. Opefi, Martine Ziliox, Amiram Hirshfeld, Ekaterina Zaitseva, Reiner Vogel, Mordechai Sheves, Philip J. Reeves, Steven O. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68145e548cf44632bc7c5e853a70c0e6
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spelling	oai:doaj.org-article:68145e548cf44632bc7c5e853a70c0e62021-12-02T14:39:16ZRetinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation10.1038/ncomms126832041-1723https://doaj.org/article/68145e548cf44632bc7c5e853a70c0e62016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12683https://doaj.org/toc/2041-1723Rhodopsin signalling is triggered by the light-induced isomerization of its 11-cisretinal chromophore. Here, the authors use NMR spectroscopy to define retinal orientation and interactions in the active metarhodopsin II intermediate, proposing a two-stage mechanism for rhodopsin activation.Naoki KimataAndreyah PopeMarkus EilersChikwado A. OpefiMartine ZilioxAmiram HirshfeldEkaterina ZaitsevaReiner VogelMordechai ShevesPhilip J. ReevesSteven O. SmithNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naoki Kimata Andreyah Pope Markus Eilers Chikwado A. Opefi Martine Ziliox Amiram Hirshfeld Ekaterina Zaitseva Reiner Vogel Mordechai Sheves Philip J. Reeves Steven O. Smith Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation
description	Rhodopsin signalling is triggered by the light-induced isomerization of its 11-cisretinal chromophore. Here, the authors use NMR spectroscopy to define retinal orientation and interactions in the active metarhodopsin II intermediate, proposing a two-stage mechanism for rhodopsin activation.
format	article
author	Naoki Kimata Andreyah Pope Markus Eilers Chikwado A. Opefi Martine Ziliox Amiram Hirshfeld Ekaterina Zaitseva Reiner Vogel Mordechai Sheves Philip J. Reeves Steven O. Smith
author_facet	Naoki Kimata Andreyah Pope Markus Eilers Chikwado A. Opefi Martine Ziliox Amiram Hirshfeld Ekaterina Zaitseva Reiner Vogel Mordechai Sheves Philip J. Reeves Steven O. Smith
author_sort	Naoki Kimata
title	Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation
title_short	Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation
title_full	Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation
title_fullStr	Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation
title_full_unstemmed	Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation
title_sort	retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/68145e548cf44632bc7c5e853a70c0e6
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Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation

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