Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation

The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 (p27) folds upon binding to Cdk/cyclin complexes and during cell cycle progression p27 becomes phosphorylated, which triggers its ubiquitination and degradation. Here the authors use an integrated approach and show that Cdk2/cyclin A-bound p27 samp...

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Autores principales:	Maksym Tsytlonok, Hugo Sanabria, Yuefeng Wang, Suren Felekyan, Katherina Hemmen, Aaron H. Phillips, Mi-Kyung Yun, M. Brett Waddell, Cheon-Gil Park, Sivaraja Vaithiyalingam, Luigi Iconaru, Stephen W. White, Peter Tompa, Claus A. M. Seidel, Richard Kriwacki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68150062dc9d4c4082ba200461d73f70
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spelling	oai:doaj.org-article:68150062dc9d4c4082ba200461d73f702021-12-02T17:02:08ZDynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation10.1038/s41467-019-09446-w2041-1723https://doaj.org/article/68150062dc9d4c4082ba200461d73f702019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09446-whttps://doaj.org/toc/2041-1723The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 (p27) folds upon binding to Cdk/cyclin complexes and during cell cycle progression p27 becomes phosphorylated, which triggers its ubiquitination and degradation. Here the authors use an integrated approach and show that Cdk2/cyclin A-bound p27 samples lowly-populated conformations that dynamically anticipate the sequential steps of the signaling cascade.Maksym TsytlonokHugo SanabriaYuefeng WangSuren FelekyanKatherina HemmenAaron H. PhillipsMi-Kyung YunM. Brett WaddellCheon-Gil ParkSivaraja VaithiyalingamLuigi IconaruStephen W. WhitePeter TompaClaus A. M. SeidelRichard KriwackiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maksym Tsytlonok Hugo Sanabria Yuefeng Wang Suren Felekyan Katherina Hemmen Aaron H. Phillips Mi-Kyung Yun M. Brett Waddell Cheon-Gil Park Sivaraja Vaithiyalingam Luigi Iconaru Stephen W. White Peter Tompa Claus A. M. Seidel Richard Kriwacki Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
description	The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 (p27) folds upon binding to Cdk/cyclin complexes and during cell cycle progression p27 becomes phosphorylated, which triggers its ubiquitination and degradation. Here the authors use an integrated approach and show that Cdk2/cyclin A-bound p27 samples lowly-populated conformations that dynamically anticipate the sequential steps of the signaling cascade.
format	article
author	Maksym Tsytlonok Hugo Sanabria Yuefeng Wang Suren Felekyan Katherina Hemmen Aaron H. Phillips Mi-Kyung Yun M. Brett Waddell Cheon-Gil Park Sivaraja Vaithiyalingam Luigi Iconaru Stephen W. White Peter Tompa Claus A. M. Seidel Richard Kriwacki
author_facet	Maksym Tsytlonok Hugo Sanabria Yuefeng Wang Suren Felekyan Katherina Hemmen Aaron H. Phillips Mi-Kyung Yun M. Brett Waddell Cheon-Gil Park Sivaraja Vaithiyalingam Luigi Iconaru Stephen W. White Peter Tompa Claus A. M. Seidel Richard Kriwacki
author_sort	Maksym Tsytlonok
title	Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
title_short	Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
title_full	Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
title_fullStr	Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
title_full_unstemmed	Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
title_sort	dynamic anticipation by cdk2/cyclin a-bound p27 mediates signal integration in cell cycle regulation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/68150062dc9d4c4082ba200461d73f70
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Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation

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