Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture

Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture

In vitro expansion of human epidermal keratinocytes to resurface severe wound defects still relies on a human/mouse xenograft culture system. Here the authors develop a fully human, xeno-free culture system using skin-associated laminins, normally present in vivo, to replace mouse feeder cells.

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Autores principales: Monica Suryana Tjin, Alvin Wen Choong Chua, Aida Moreno-Moral, Li Yen Chong, Po Yin Tang, Nathan Peter Harmston, Zuhua Cai, Enrico Petretto, Bien Keem Tan, Karl Tryggvason
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/6816bfa2e9c245778f6cdd8f174d79bb
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spelling oai:doaj.org-article:6816bfa2e9c245778f6cdd8f174d79bb2021-12-02T16:49:50ZBiologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture10.1038/s41467-018-06934-32041-1723https://doaj.org/article/6816bfa2e9c245778f6cdd8f174d79bb2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06934-3https://doaj.org/toc/2041-1723In vitro expansion of human epidermal keratinocytes to resurface severe wound defects still relies on a human/mouse xenograft culture system. Here the authors develop a fully human, xeno-free culture system using skin-associated laminins, normally present in vivo, to replace mouse feeder cells.Monica Suryana TjinAlvin Wen Choong ChuaAida Moreno-MoralLi Yen ChongPo Yin TangNathan Peter HarmstonZuhua CaiEnrico PetrettoBien Keem TanKarl TryggvasonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Monica Suryana Tjin
Alvin Wen Choong Chua
Aida Moreno-Moral
Li Yen Chong
Po Yin Tang
Nathan Peter Harmston
Zuhua Cai
Enrico Petretto
Bien Keem Tan
Karl Tryggvason
Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
description In vitro expansion of human epidermal keratinocytes to resurface severe wound defects still relies on a human/mouse xenograft culture system. Here the authors develop a fully human, xeno-free culture system using skin-associated laminins, normally present in vivo, to replace mouse feeder cells.
format article
author Monica Suryana Tjin
Alvin Wen Choong Chua
Aida Moreno-Moral
Li Yen Chong
Po Yin Tang
Nathan Peter Harmston
Zuhua Cai
Enrico Petretto
Bien Keem Tan
Karl Tryggvason
author_facet Monica Suryana Tjin
Alvin Wen Choong Chua
Aida Moreno-Moral
Li Yen Chong
Po Yin Tang
Nathan Peter Harmston
Zuhua Cai
Enrico Petretto
Bien Keem Tan
Karl Tryggvason
author_sort Monica Suryana Tjin
title Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
title_short Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
title_full Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
title_fullStr Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
title_full_unstemmed Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
title_sort biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6816bfa2e9c245778f6cdd8f174d79bb
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