Effect of calcium channel blockers on incidence of diabetes: a meta-analysis

Hiroshi Noto,1,2 Atsushi Goto,2 Tetsuro Tsujimoto,1 Mitsuhiko Noda1,2 1Department of Diabetes and Metabolic Medicine, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan; 2Department of Diabetes Research, Diabetes Research Center, Research Institute, National Center for Glo...

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Autores principales:	Noto H, Goto A, Tsujimoto T, Noda M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/68189daa6a6f4a69ac1f9d6d73d4fd9e
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spelling	oai:doaj.org-article:68189daa6a6f4a69ac1f9d6d73d4fd9e2021-12-02T05:28:03ZEffect of calcium channel blockers on incidence of diabetes: a meta-analysis1178-7007https://doaj.org/article/68189daa6a6f4a69ac1f9d6d73d4fd9e2013-07-01T00:00:00Zhttp://www.dovepress.com/effect-of-calcium-channel-blockers-on-incidence-of-diabetes-a-meta-ana-a13812https://doaj.org/toc/1178-7007Hiroshi Noto,1,2 Atsushi Goto,2 Tetsuro Tsujimoto,1 Mitsuhiko Noda1,2 1Department of Diabetes and Metabolic Medicine, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan; 2Department of Diabetes Research, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Aims: Insulin resistance and the progressive loss of ß-cell function are components of the fundamental pathophysiology of type II diabetes. A recent experimental study suggested that calcium channel blockers (CCBs) might inhibit ß-cell apoptosis, enhance ß-cell function, and prevent diabetes. The present meta-analysis examined the clinical effect of CCBs on the incidence of diabetes. Methods: MEDLINE, EMBASE, ISI Web of Science, the Cochrane Library, and ClinicalTrials.gov were each searched for relevant articles published up to March 11, 2013. Randomized controlled trials (RCTs) with a follow-up period of at least 1-year were included. Identified articles were systematically reviewed, and those with pertinent data were selected for inclusion in a meta-analysis. Results: We included ten RCTs in a meta-analysis. Of the 108,118 people with hypertension and no pre-existing diabetes, 7,073 (6.5%) cases of type II diabetes were reported. CCBs were associated with a higher incidence of diabetes than angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs; pooled risk ratios [95% confidence intervals]: 1.23 [1.01–1.51] and 1.27 [1.14–1.42], respectively) and a lower incidence compared with ß blockers or diuretics (0.83 [0.73–0.94] and 0.82 [0.69–0.98], respectively). The overall risk of diabetes among subjects taking CCBs was not significant (0.99 [0.85–1.15]). Conclusion: The use of CCBs was not significantly associated with incident diabetes compared to other antihypertensive agents: the association with diabetes was lowest for ACEIs and ARBs, followed by CCBs, ß blockers, and diuretics. Although CCBs can be safely used in hypertensive patients, it would be premature to advocate CCBs for the prevention or treatment of diabetes. Keywords: diabetes, calcium channel blockers, hypertension, meta-analysisNoto HGoto ATsujimoto TNoda MDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2013, Iss default, Pp 257-261 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Noto H Goto A Tsujimoto T Noda M Effect of calcium channel blockers on incidence of diabetes: a meta-analysis
description	Hiroshi Noto,1,2 Atsushi Goto,2 Tetsuro Tsujimoto,1 Mitsuhiko Noda1,2 1Department of Diabetes and Metabolic Medicine, Center Hospital, National Center for Global Health and Medicine, Tokyo, Japan; 2Department of Diabetes Research, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Aims: Insulin resistance and the progressive loss of ß-cell function are components of the fundamental pathophysiology of type II diabetes. A recent experimental study suggested that calcium channel blockers (CCBs) might inhibit ß-cell apoptosis, enhance ß-cell function, and prevent diabetes. The present meta-analysis examined the clinical effect of CCBs on the incidence of diabetes. Methods: MEDLINE, EMBASE, ISI Web of Science, the Cochrane Library, and ClinicalTrials.gov were each searched for relevant articles published up to March 11, 2013. Randomized controlled trials (RCTs) with a follow-up period of at least 1-year were included. Identified articles were systematically reviewed, and those with pertinent data were selected for inclusion in a meta-analysis. Results: We included ten RCTs in a meta-analysis. Of the 108,118 people with hypertension and no pre-existing diabetes, 7,073 (6.5%) cases of type II diabetes were reported. CCBs were associated with a higher incidence of diabetes than angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs; pooled risk ratios [95% confidence intervals]: 1.23 [1.01–1.51] and 1.27 [1.14–1.42], respectively) and a lower incidence compared with ß blockers or diuretics (0.83 [0.73–0.94] and 0.82 [0.69–0.98], respectively). The overall risk of diabetes among subjects taking CCBs was not significant (0.99 [0.85–1.15]). Conclusion: The use of CCBs was not significantly associated with incident diabetes compared to other antihypertensive agents: the association with diabetes was lowest for ACEIs and ARBs, followed by CCBs, ß blockers, and diuretics. Although CCBs can be safely used in hypertensive patients, it would be premature to advocate CCBs for the prevention or treatment of diabetes. Keywords: diabetes, calcium channel blockers, hypertension, meta-analysis
format	article
author	Noto H Goto A Tsujimoto T Noda M
author_facet	Noto H Goto A Tsujimoto T Noda M
author_sort	Noto H
title	Effect of calcium channel blockers on incidence of diabetes: a meta-analysis
title_short	Effect of calcium channel blockers on incidence of diabetes: a meta-analysis
title_full	Effect of calcium channel blockers on incidence of diabetes: a meta-analysis
title_fullStr	Effect of calcium channel blockers on incidence of diabetes: a meta-analysis
title_full_unstemmed	Effect of calcium channel blockers on incidence of diabetes: a meta-analysis
title_sort	effect of calcium channel blockers on incidence of diabetes: a meta-analysis
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/68189daa6a6f4a69ac1f9d6d73d4fd9e
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Effect of calcium channel blockers on incidence of diabetes: a meta-analysis

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