Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

The decapping enzyme Dcp2 removes the 5′ eukaryotic cap from mRNA transcripts and acts in concert with its essential activator Dcp1 and various coactivators. Here the authors present the structure of the fully-activated mRNA decapping complex, which reveals how Dcp2 recognizes the cap substrate and...

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Autores principales:	Jeffrey S. Mugridge, Ryan W. Tibble, Marcin Ziemniak, Jacek Jemielity, John D. Gross
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/681911898ec044a5a3ff6a9259b7e8b3
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spelling	oai:doaj.org-article:681911898ec044a5a3ff6a9259b7e8b32021-12-02T15:34:29ZStructure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis10.1038/s41467-018-03536-x2041-1723https://doaj.org/article/681911898ec044a5a3ff6a9259b7e8b32018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03536-xhttps://doaj.org/toc/2041-1723The decapping enzyme Dcp2 removes the 5′ eukaryotic cap from mRNA transcripts and acts in concert with its essential activator Dcp1 and various coactivators. Here the authors present the structure of the fully-activated mRNA decapping complex, which reveals how Dcp2 recognizes the cap substrate and coactivators Edc1 and Edc3 activate catalysis.Jeffrey S. MugridgeRyan W. TibbleMarcin ZiemniakJacek JemielityJohn D. GrossNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffrey S. Mugridge Ryan W. Tibble Marcin Ziemniak Jacek Jemielity John D. Gross Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis
description	The decapping enzyme Dcp2 removes the 5′ eukaryotic cap from mRNA transcripts and acts in concert with its essential activator Dcp1 and various coactivators. Here the authors present the structure of the fully-activated mRNA decapping complex, which reveals how Dcp2 recognizes the cap substrate and coactivators Edc1 and Edc3 activate catalysis.
format	article
author	Jeffrey S. Mugridge Ryan W. Tibble Marcin Ziemniak Jacek Jemielity John D. Gross
author_facet	Jeffrey S. Mugridge Ryan W. Tibble Marcin Ziemniak Jacek Jemielity John D. Gross
author_sort	Jeffrey S. Mugridge
title	Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis
title_short	Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis
title_full	Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis
title_fullStr	Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis
title_full_unstemmed	Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis
title_sort	structure of the activated edc1-dcp1-dcp2-edc3 mrna decapping complex with substrate analog poised for catalysis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/681911898ec044a5a3ff6a9259b7e8b3
work_keys_str_mv	AT jeffreysmugridge structureoftheactivatededc1dcp1dcp2edc3mrnadecappingcomplexwithsubstrateanalogpoisedforcatalysis AT ryanwtibble structureoftheactivatededc1dcp1dcp2edc3mrnadecappingcomplexwithsubstrateanalogpoisedforcatalysis AT marcinziemniak structureoftheactivatededc1dcp1dcp2edc3mrnadecappingcomplexwithsubstrateanalogpoisedforcatalysis AT jacekjemielity structureoftheactivatededc1dcp1dcp2edc3mrnadecappingcomplexwithsubstrateanalogpoisedforcatalysis AT johndgross structureoftheactivatededc1dcp1dcp2edc3mrnadecappingcomplexwithsubstrateanalogpoisedforcatalysis
_version_	1718386841038618624

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

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