Vitamin D responsive elements within the HLA-DRB1 promoter region in Sardinian multiple sclerosis associated alleles.

Vitamin D responsive elements within the HLA-DRB1 promoter region in Sardinian multiple sclerosis associated alleles.

Vitamin D response elements (VDREs) have been found in the promoter region of the MS-associated allele HLA-DRB1*15:01, suggesting that with low vitamin D availability VDREs are incapable of inducing *15:01 expression allowing in early life autoreactive T-cells to escape central thymic deletion. The...

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Autores principales: Eleonora Cocco, Alessandra Meloni, Maria Rita Murru, Daniela Corongiu, Stefania Tranquilli, Elisabetta Fadda, Raffaele Murru, Lucia Schirru, Maria Antonietta Secci, Gianna Costa, Isadora Asunis, Stefania Cuccu, Giuseppe Fenu, Lorena Lorefice, Nicola Carboni, Gioia Mura, Maria Cristina Rosatelli, Maria Giovanna Marrosu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/681972ee6990452aa896122b232f7594
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