Optical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome

Samuel F Passi,1,2 Cassandra C Brooks,1 Atalie C Thompson,1 Preeya K Gupta1 1Department of Ophthalmology, Duke University, Durham, NC, USA; 2Minnesota Eye Consultants, Bloomington, MN, USACorrespondence: Preeya K Gupta Email preeya.gupta@duke.eduPurpose: To evaluate the optical quality and tear film...

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Autores principales:	Passi SF, Brooks CC, Thompson AC, Gupta PK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	neurostimulation objective scatter index modulation transfer function dry eye syndrome Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/681a6114e5754ea5ab176b9f20950ba6
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spelling	oai:doaj.org-article:681a6114e5754ea5ab176b9f20950ba62021-12-02T10:08:49ZOptical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome1177-5483https://doaj.org/article/681a6114e5754ea5ab176b9f20950ba62020-07-01T00:00:00Zhttps://www.dovepress.com/optical-quality-and-tear-film-analysis-before-and-after-intranasal-sti-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Samuel F Passi,1,2 Cassandra C Brooks,1 Atalie C Thompson,1 Preeya K Gupta1 1Department of Ophthalmology, Duke University, Durham, NC, USA; 2Minnesota Eye Consultants, Bloomington, MN, USACorrespondence: Preeya K Gupta Email preeya.gupta@duke.eduPurpose: To evaluate the optical quality and tear film quality in patients with dry eye syndrome (DES) before and after using an intranasal neurostimulation device to stimulate tear production.Methods: Cross-sectional review of 33 eyes in 21 patients with DES who underwent optical quality and tear film analysis as part of their routine dry eye evaluation pre- and post-neurostimulation trial in office. Optical quality was assessed by measuring the objective scattering index (OSI) and modulation transfer function (MTF). The time to blink and mean tear film OSI were used to analyze the tear film.Results: Optical quality after the use of the intranasal neurostimulator improved with an average decrease (improvement) in OSI of 0.30± 0.68 (P=0.015) and an average increase (improvement) in MTF of 2.12± 9.2 (P=0.15). Pre-intranasal neurostimulation OSI had a positive correlation with age (Spearman’s rho 0.60, p < 0.001), while MTF had a negative correlation (Spearman’s rho − 0.38, p = 0.03). Pre-intranasal neurostimulation OSI had a negative correlation with MTF (Spearman’s rho − 0.85, p < 0.001) and a positive correlation with tear film mean OSI (Spearman’s rho 0.85, p < 0.001).Conclusion: The optical quality of patients with DES is improved with the use of intranasal neurostimulation for tear production, and there was a trend towards improved MTF though not statistically significant. Future studies are needed to follow patients longitudinally.Keywords: neurostimulation, objective scatter index, modulation transfer function, dry eye syndromePassi SFBrooks CCThompson ACGupta PKDove Medical Pressarticleneurostimulationobjective scatter indexmodulation transfer functiondry eye syndromeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1987-1992 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurostimulation objective scatter index modulation transfer function dry eye syndrome Ophthalmology RE1-994
spellingShingle	neurostimulation objective scatter index modulation transfer function dry eye syndrome Ophthalmology RE1-994 Passi SF Brooks CC Thompson AC Gupta PK Optical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome
description	Samuel F Passi,1,2 Cassandra C Brooks,1 Atalie C Thompson,1 Preeya K Gupta1 1Department of Ophthalmology, Duke University, Durham, NC, USA; 2Minnesota Eye Consultants, Bloomington, MN, USACorrespondence: Preeya K Gupta Email preeya.gupta@duke.eduPurpose: To evaluate the optical quality and tear film quality in patients with dry eye syndrome (DES) before and after using an intranasal neurostimulation device to stimulate tear production.Methods: Cross-sectional review of 33 eyes in 21 patients with DES who underwent optical quality and tear film analysis as part of their routine dry eye evaluation pre- and post-neurostimulation trial in office. Optical quality was assessed by measuring the objective scattering index (OSI) and modulation transfer function (MTF). The time to blink and mean tear film OSI were used to analyze the tear film.Results: Optical quality after the use of the intranasal neurostimulator improved with an average decrease (improvement) in OSI of 0.30± 0.68 (P=0.015) and an average increase (improvement) in MTF of 2.12± 9.2 (P=0.15). Pre-intranasal neurostimulation OSI had a positive correlation with age (Spearman’s rho 0.60, p < 0.001), while MTF had a negative correlation (Spearman’s rho − 0.38, p = 0.03). Pre-intranasal neurostimulation OSI had a negative correlation with MTF (Spearman’s rho − 0.85, p < 0.001) and a positive correlation with tear film mean OSI (Spearman’s rho 0.85, p < 0.001).Conclusion: The optical quality of patients with DES is improved with the use of intranasal neurostimulation for tear production, and there was a trend towards improved MTF though not statistically significant. Future studies are needed to follow patients longitudinally.Keywords: neurostimulation, objective scatter index, modulation transfer function, dry eye syndrome
format	article
author	Passi SF Brooks CC Thompson AC Gupta PK
author_facet	Passi SF Brooks CC Thompson AC Gupta PK
author_sort	Passi SF
title	Optical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome
title_short	Optical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome
title_full	Optical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome
title_fullStr	Optical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome
title_full_unstemmed	Optical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome
title_sort	optical quality and tear film analysis before and after intranasal stimulation in patients with dry eye syndrome
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/681a6114e5754ea5ab176b9f20950ba6
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_version_	1718397583917842432

Optical Quality and Tear Film Analysis Before and After Intranasal Stimulation in Patients with Dry Eye Syndrome

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