Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice

Dependence of hematopoietic stem cell (HSC) fate on the phase of the cell cycle has not been demonstrated in vivo. Here, the authors find that HSCs can differentiate into a downstream progenitor without physical division, even before progressing into the S phase of the cell cycle.

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Autores principales:	Tatyana Grinenko, Anne Eugster, Lars Thielecke, Beáta Ramasz, Anja Krüger, Sevina Dietz, Ingmar Glauche, Alexander Gerbaulet, Malte von Bonin, Onur Basak, Hans Clevers, Triantafyllos Chavakis, Ben Wielockx
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/681a9eaa5b95419b80609eae18b557be
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spelling	oai:doaj.org-article:681a9eaa5b95419b80609eae18b557be2021-12-02T17:31:57ZHematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice10.1038/s41467-018-04188-72041-1723https://doaj.org/article/681a9eaa5b95419b80609eae18b557be2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04188-7https://doaj.org/toc/2041-1723Dependence of hematopoietic stem cell (HSC) fate on the phase of the cell cycle has not been demonstrated in vivo. Here, the authors find that HSCs can differentiate into a downstream progenitor without physical division, even before progressing into the S phase of the cell cycle.Tatyana GrinenkoAnne EugsterLars ThieleckeBeáta RamaszAnja KrügerSevina DietzIngmar GlaucheAlexander GerbauletMalte von BoninOnur BasakHans CleversTriantafyllos ChavakisBen WielockxNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tatyana Grinenko Anne Eugster Lars Thielecke Beáta Ramasz Anja Krüger Sevina Dietz Ingmar Glauche Alexander Gerbaulet Malte von Bonin Onur Basak Hans Clevers Triantafyllos Chavakis Ben Wielockx Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice
description	Dependence of hematopoietic stem cell (HSC) fate on the phase of the cell cycle has not been demonstrated in vivo. Here, the authors find that HSCs can differentiate into a downstream progenitor without physical division, even before progressing into the S phase of the cell cycle.
format	article
author	Tatyana Grinenko Anne Eugster Lars Thielecke Beáta Ramasz Anja Krüger Sevina Dietz Ingmar Glauche Alexander Gerbaulet Malte von Bonin Onur Basak Hans Clevers Triantafyllos Chavakis Ben Wielockx
author_facet	Tatyana Grinenko Anne Eugster Lars Thielecke Beáta Ramasz Anja Krüger Sevina Dietz Ingmar Glauche Alexander Gerbaulet Malte von Bonin Onur Basak Hans Clevers Triantafyllos Chavakis Ben Wielockx
author_sort	Tatyana Grinenko
title	Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice
title_short	Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice
title_full	Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice
title_fullStr	Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice
title_full_unstemmed	Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice
title_sort	hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/681a9eaa5b95419b80609eae18b557be
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Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice

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