Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery)

Randomized studies to assess the efficacy of Mohs micrographic surgery in basal cell and squamous cell carcinomas are limited by methodological and ethical issues and a lack of long follow-up periods. This study presents the “real-life” results of a nationwide 7-years cohort on basal cell carcinoma...

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Autores principales:	Alejandra Tomás-Velázquez, Onofre Sanmartin-Jiménez, Joan R. Garcés, Manuel A. Rodríguez-Prieto, Verónica Ruiz-Salas, Esther de Eusebio-Murillo, Román Miñano-Medrano, Begoña Escutia-Muñoz, Ángeles Flórez-Menéndez, Juan L. Artola-Igarza, Alberto Alfaro-Rubio, Pilar Gil, Yolanda Delgado-Jiménez, Julia M. Sanchez-Schmidt, Irati Allende-Markixana, María L. Alonso-Pacheco, Beatriz García-Bracamonte, Pablo de la Cueva-Dobao, Raquel Navarro-Tejedor, Cristina Ciudad-Blanco, Lucía Carnero-González, Hugo Vázquez-Veiga, Natividad Cano-Martínez, Eva Vilarrasa-Rull, Pedro Sanchez-Sambucety, José L. López-Estebaranz, Rafael Botella-Estrada, Beatriz Gonzalez-Sixto, Antonio Martorell-Calatayud, Victoriano Morales-Gordillo, Agustí Toll-Abelló, Izascun Ocerin-Guerra, Matías Mayor-Arenal, Ricardo Suárez-Fernández, Laura Sainz-Gaspar, Miguel A. Descalzo, Ignacio García-Doval, Pedro Redondo
Formato:	article
Lenguaje:	EN
Publicado:	Society for Publication of Acta Dermato-Venereologica 2021
Materias:	basal cell carcinoma squamous cell carcinoma Mohs surgery recurrence risk factors Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/681dd3175485489f8fe0b520e3945bea
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spelling	oai:doaj.org-article:681dd3175485489f8fe0b520e3945bea2021-11-24T13:53:59ZRisk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery)10.2340/actadv.v101.5440001-55551651-2057https://doaj.org/article/681dd3175485489f8fe0b520e3945bea2021-11-01T00:00:00Zhttps://medicaljournalssweden.se/actadv/article/view/544https://doaj.org/toc/0001-5555https://doaj.org/toc/1651-2057Randomized studies to assess the efficacy of Mohs micrographic surgery in basal cell and squamous cell carcinomas are limited by methodological and ethical issues and a lack of long follow-up periods. This study presents the “real-life” results of a nationwide 7-years cohort on basal cell carcinoma and squamous cell carcinoma treated with Mohs micrographic surgery. A prospective cohort was conducted in 22 Spanish centres (from July 2013 to February 2020) and a multivariate analysis, including characteristics of patients, tumours, surgeries and follow-up, was performed. A total of 4,402 patients followed up for 12,111 patient-years for basal cell carcinoma, and 371 patients with 915 patient-years of follow-up for squamous cell carcinoma were recruited. Risk factors for recurrence included age, non-primary tumours and more stages or unfinished surgeries for both tumours, and immunosuppression for squamous cell carcinoma. Incidence rates of recurrence were 1.3 per 100 person-years for basal cell carcinoma (95% confidence interval 1.1–1.5) and 4.5 for squamous cell carcinoma (95% confidence interval 3.3–6.1), being constant over time (0–5 years). In conclusion, follow-up strategies should be equally intense for at least the first 5 years, with special attention paid to squamous cell carcinoma (especially in immunosuppressed patients), elderly patients, non-primary tumours, and those procedures requiring more stages, or unfinished surgeries. Alejandra Tomás-VelázquezOnofre Sanmartin-JiménezJoan R. GarcésManuel A. Rodríguez-PrietoVerónica Ruiz-SalasEsther de Eusebio-MurilloRomán Miñano-MedranoBegoña Escutia-MuñozÁngeles Flórez-MenéndezJuan L. Artola-IgarzaAlberto Alfaro-RubioPilar GilYolanda Delgado-JiménezJulia M. Sanchez-SchmidtIrati Allende-MarkixanaMaría L. Alonso-PachecoBeatriz García-BracamontePablo de la Cueva-DobaoRaquel Navarro-TejedorCristina Ciudad-BlancoLucía Carnero-GonzálezHugo Vázquez-VeigaNatividad Cano-MartínezEva Vilarrasa-RullPedro Sanchez-SambucetyJosé L. López-EstebaranzRafael Botella-EstradaBeatriz Gonzalez-SixtoAntonio Martorell-CalatayudVictoriano Morales-GordilloAgustí Toll-AbellóIzascun Ocerin-GuerraMatías Mayor-ArenalRicardo Suárez-FernándezLaura Sainz-GasparMiguel A. DescalzoIgnacio García-DovalPedro RedondoSociety for Publication of Acta Dermato-Venereologicaarticlebasal cell carcinomasquamous cell carcinomaMohs surgeryrecurrencerisk factorsDermatologyRL1-803ENActa Dermato-Venereologica, Vol 101, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	basal cell carcinoma squamous cell carcinoma Mohs surgery recurrence risk factors Dermatology RL1-803
spellingShingle	basal cell carcinoma squamous cell carcinoma Mohs surgery recurrence risk factors Dermatology RL1-803 Alejandra Tomás-Velázquez Onofre Sanmartin-Jiménez Joan R. Garcés Manuel A. Rodríguez-Prieto Verónica Ruiz-Salas Esther de Eusebio-Murillo Román Miñano-Medrano Begoña Escutia-Muñoz Ángeles Flórez-Menéndez Juan L. Artola-Igarza Alberto Alfaro-Rubio Pilar Gil Yolanda Delgado-Jiménez Julia M. Sanchez-Schmidt Irati Allende-Markixana María L. Alonso-Pacheco Beatriz García-Bracamonte Pablo de la Cueva-Dobao Raquel Navarro-Tejedor Cristina Ciudad-Blanco Lucía Carnero-González Hugo Vázquez-Veiga Natividad Cano-Martínez Eva Vilarrasa-Rull Pedro Sanchez-Sambucety José L. López-Estebaranz Rafael Botella-Estrada Beatriz Gonzalez-Sixto Antonio Martorell-Calatayud Victoriano Morales-Gordillo Agustí Toll-Abelló Izascun Ocerin-Guerra Matías Mayor-Arenal Ricardo Suárez-Fernández Laura Sainz-Gaspar Miguel A. Descalzo Ignacio García-Doval Pedro Redondo Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery)
description	Randomized studies to assess the efficacy of Mohs micrographic surgery in basal cell and squamous cell carcinomas are limited by methodological and ethical issues and a lack of long follow-up periods. This study presents the “real-life” results of a nationwide 7-years cohort on basal cell carcinoma and squamous cell carcinoma treated with Mohs micrographic surgery. A prospective cohort was conducted in 22 Spanish centres (from July 2013 to February 2020) and a multivariate analysis, including characteristics of patients, tumours, surgeries and follow-up, was performed. A total of 4,402 patients followed up for 12,111 patient-years for basal cell carcinoma, and 371 patients with 915 patient-years of follow-up for squamous cell carcinoma were recruited. Risk factors for recurrence included age, non-primary tumours and more stages or unfinished surgeries for both tumours, and immunosuppression for squamous cell carcinoma. Incidence rates of recurrence were 1.3 per 100 person-years for basal cell carcinoma (95% confidence interval 1.1–1.5) and 4.5 for squamous cell carcinoma (95% confidence interval 3.3–6.1), being constant over time (0–5 years). In conclusion, follow-up strategies should be equally intense for at least the first 5 years, with special attention paid to squamous cell carcinoma (especially in immunosuppressed patients), elderly patients, non-primary tumours, and those procedures requiring more stages, or unfinished surgeries.
format	article
author	Alejandra Tomás-Velázquez Onofre Sanmartin-Jiménez Joan R. Garcés Manuel A. Rodríguez-Prieto Verónica Ruiz-Salas Esther de Eusebio-Murillo Román Miñano-Medrano Begoña Escutia-Muñoz Ángeles Flórez-Menéndez Juan L. Artola-Igarza Alberto Alfaro-Rubio Pilar Gil Yolanda Delgado-Jiménez Julia M. Sanchez-Schmidt Irati Allende-Markixana María L. Alonso-Pacheco Beatriz García-Bracamonte Pablo de la Cueva-Dobao Raquel Navarro-Tejedor Cristina Ciudad-Blanco Lucía Carnero-González Hugo Vázquez-Veiga Natividad Cano-Martínez Eva Vilarrasa-Rull Pedro Sanchez-Sambucety José L. López-Estebaranz Rafael Botella-Estrada Beatriz Gonzalez-Sixto Antonio Martorell-Calatayud Victoriano Morales-Gordillo Agustí Toll-Abelló Izascun Ocerin-Guerra Matías Mayor-Arenal Ricardo Suárez-Fernández Laura Sainz-Gaspar Miguel A. Descalzo Ignacio García-Doval Pedro Redondo
author_facet	Alejandra Tomás-Velázquez Onofre Sanmartin-Jiménez Joan R. Garcés Manuel A. Rodríguez-Prieto Verónica Ruiz-Salas Esther de Eusebio-Murillo Román Miñano-Medrano Begoña Escutia-Muñoz Ángeles Flórez-Menéndez Juan L. Artola-Igarza Alberto Alfaro-Rubio Pilar Gil Yolanda Delgado-Jiménez Julia M. Sanchez-Schmidt Irati Allende-Markixana María L. Alonso-Pacheco Beatriz García-Bracamonte Pablo de la Cueva-Dobao Raquel Navarro-Tejedor Cristina Ciudad-Blanco Lucía Carnero-González Hugo Vázquez-Veiga Natividad Cano-Martínez Eva Vilarrasa-Rull Pedro Sanchez-Sambucety José L. López-Estebaranz Rafael Botella-Estrada Beatriz Gonzalez-Sixto Antonio Martorell-Calatayud Victoriano Morales-Gordillo Agustí Toll-Abelló Izascun Ocerin-Guerra Matías Mayor-Arenal Ricardo Suárez-Fernández Laura Sainz-Gaspar Miguel A. Descalzo Ignacio García-Doval Pedro Redondo
author_sort	Alejandra Tomás-Velázquez
title	Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery)
title_short	Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery)
title_full	Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery)
title_fullStr	Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery)
title_full_unstemmed	Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery)
title_sort	risk factors and rate of recurrence after mohs surgery in basal cell and squamous cell carcinomas: a nationwide prospective cohort (regesmohs, spanish registry of mohs surgery)
publisher	Society for Publication of Acta Dermato-Venereologica
publishDate	2021
url	https://doaj.org/article/681dd3175485489f8fe0b520e3945bea
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Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort (REGESMOHS, Spanish Registry of Mohs Surgery)

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