Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation

Redweik et al. explore mechanisms underlying the effects of reserpine treatment on Salmonella-infected explants from chicken intestine as well as the effects on the intestine in vivo following oral treatment. They demonstrate that several signaling pathways (norepinephrine, mTOR, epidermal growth fa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Graham A. J. Redweik, Michael H. Kogut, Ryan J. Arsenault, Mark Lyte, Melha Mellata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6820df943eeb4c54986abc1bc1bf6237
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6820df943eeb4c54986abc1bc1bf6237
record_format	dspace
spelling	oai:doaj.org-article:6820df943eeb4c54986abc1bc1bf62372021-12-05T12:08:14ZReserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation10.1038/s42003-021-02888-32399-3642https://doaj.org/article/6820df943eeb4c54986abc1bc1bf62372021-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02888-3https://doaj.org/toc/2399-3642Redweik et al. explore mechanisms underlying the effects of reserpine treatment on Salmonella-infected explants from chicken intestine as well as the effects on the intestine in vivo following oral treatment. They demonstrate that several signaling pathways (norepinephrine, mTOR, epidermal growth factor) contribute to these reserpine-induced antimicrobial responses, with MEK1/2 playing a central role.Graham A. J. RedweikMichael H. KogutRyan J. ArsenaultMark LyteMelha MellataNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Graham A. J. Redweik Michael H. Kogut Ryan J. Arsenault Mark Lyte Melha Mellata Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation
description	Redweik et al. explore mechanisms underlying the effects of reserpine treatment on Salmonella-infected explants from chicken intestine as well as the effects on the intestine in vivo following oral treatment. They demonstrate that several signaling pathways (norepinephrine, mTOR, epidermal growth factor) contribute to these reserpine-induced antimicrobial responses, with MEK1/2 playing a central role.
format	article
author	Graham A. J. Redweik Michael H. Kogut Ryan J. Arsenault Mark Lyte Melha Mellata
author_facet	Graham A. J. Redweik Michael H. Kogut Ryan J. Arsenault Mark Lyte Melha Mellata
author_sort	Graham A. J. Redweik
title	Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation
title_short	Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation
title_full	Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation
title_fullStr	Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation
title_full_unstemmed	Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation
title_sort	reserpine improves enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and mek1/2 activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6820df943eeb4c54986abc1bc1bf6237
work_keys_str_mv	AT grahamajredweik reserpineimprovesenterobacteriaceaeresistanceinchickenintestinevianeuroimmunometabolicsignalingandmek12activation AT michaelhkogut reserpineimprovesenterobacteriaceaeresistanceinchickenintestinevianeuroimmunometabolicsignalingandmek12activation AT ryanjarsenault reserpineimprovesenterobacteriaceaeresistanceinchickenintestinevianeuroimmunometabolicsignalingandmek12activation AT marklyte reserpineimprovesenterobacteriaceaeresistanceinchickenintestinevianeuroimmunometabolicsignalingandmek12activation AT melhamellata reserpineimprovesenterobacteriaceaeresistanceinchickenintestinevianeuroimmunometabolicsignalingandmek12activation
_version_	1718372196846403584

Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation

Ejemplares similares