Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
p53 isoform Δ133p53β is reported to promote intrinsic oncogenic functions. Here the authors show Δ133p53β is sequestered as aggregates in an inactive form, while association with interacting partners including p63 isoforms and the CCT chaperone complex promotes Δ133p53β activity, resulting in enhanc...
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Nature Portfolio
2021
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oai:doaj.org-article:68225466d9dc4ec1bb5844837f0a0ec82021-12-02T17:23:48ZΔ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells10.1038/s41467-021-25550-22041-1723https://doaj.org/article/68225466d9dc4ec1bb5844837f0a0ec82021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25550-2https://doaj.org/toc/2041-1723p53 isoform Δ133p53β is reported to promote intrinsic oncogenic functions. Here the authors show Δ133p53β is sequestered as aggregates in an inactive form, while association with interacting partners including p63 isoforms and the CCT chaperone complex promotes Δ133p53β activity, resulting in enhanced cancer cell migration and invasion.Nikola ArsicTania SlatterGilles GadeaEtienne VillainAurelie FournetMarina KazantsevaFrédéric AllemandNathalie SibilleMartial SevenoSylvain de RossiSunali MehtaSerge UrbachJean-Christophe BourdonPau BernadoAndrey V. KajavaAntony BraithwaitePierre RouxNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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Science Q Nikola Arsic Tania Slatter Gilles Gadea Etienne Villain Aurelie Fournet Marina Kazantseva Frédéric Allemand Nathalie Sibille Martial Seveno Sylvain de Rossi Sunali Mehta Serge Urbach Jean-Christophe Bourdon Pau Bernado Andrey V. Kajava Antony Braithwaite Pierre Roux Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells |
description |
p53 isoform Δ133p53β is reported to promote intrinsic oncogenic functions. Here the authors show Δ133p53β is sequestered as aggregates in an inactive form, while association with interacting partners including p63 isoforms and the CCT chaperone complex promotes Δ133p53β activity, resulting in enhanced cancer cell migration and invasion. |
format |
article |
author |
Nikola Arsic Tania Slatter Gilles Gadea Etienne Villain Aurelie Fournet Marina Kazantseva Frédéric Allemand Nathalie Sibille Martial Seveno Sylvain de Rossi Sunali Mehta Serge Urbach Jean-Christophe Bourdon Pau Bernado Andrey V. Kajava Antony Braithwaite Pierre Roux |
author_facet |
Nikola Arsic Tania Slatter Gilles Gadea Etienne Villain Aurelie Fournet Marina Kazantseva Frédéric Allemand Nathalie Sibille Martial Seveno Sylvain de Rossi Sunali Mehta Serge Urbach Jean-Christophe Bourdon Pau Bernado Andrey V. Kajava Antony Braithwaite Pierre Roux |
author_sort |
Nikola Arsic |
title |
Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells |
title_short |
Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells |
title_full |
Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells |
title_fullStr |
Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells |
title_full_unstemmed |
Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells |
title_sort |
δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/68225466d9dc4ec1bb5844837f0a0ec8 |
work_keys_str_mv |
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