Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells

p53 isoform Δ133p53β is reported to promote intrinsic oncogenic functions. Here the authors show Δ133p53β is sequestered as aggregates in an inactive form, while association with interacting partners including p63 isoforms and the CCT chaperone complex promotes Δ133p53β activity, resulting in enhanc...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Nikola Arsic, Tania Slatter, Gilles Gadea, Etienne Villain, Aurelie Fournet, Marina Kazantseva, Frédéric Allemand, Nathalie Sibille, Martial Seveno, Sylvain de Rossi, Sunali Mehta, Serge Urbach, Jean-Christophe Bourdon, Pau Bernado, Andrey V. Kajava, Antony Braithwaite, Pierre Roux
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/68225466d9dc4ec1bb5844837f0a0ec8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:68225466d9dc4ec1bb5844837f0a0ec8
record_format dspace
spelling oai:doaj.org-article:68225466d9dc4ec1bb5844837f0a0ec82021-12-02T17:23:48ZΔ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells10.1038/s41467-021-25550-22041-1723https://doaj.org/article/68225466d9dc4ec1bb5844837f0a0ec82021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25550-2https://doaj.org/toc/2041-1723p53 isoform Δ133p53β is reported to promote intrinsic oncogenic functions. Here the authors show Δ133p53β is sequestered as aggregates in an inactive form, while association with interacting partners including p63 isoforms and the CCT chaperone complex promotes Δ133p53β activity, resulting in enhanced cancer cell migration and invasion.Nikola ArsicTania SlatterGilles GadeaEtienne VillainAurelie FournetMarina KazantsevaFrédéric AllemandNathalie SibilleMartial SevenoSylvain de RossiSunali MehtaSerge UrbachJean-Christophe BourdonPau BernadoAndrey V. KajavaAntony BraithwaitePierre RouxNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nikola Arsic
Tania Slatter
Gilles Gadea
Etienne Villain
Aurelie Fournet
Marina Kazantseva
Frédéric Allemand
Nathalie Sibille
Martial Seveno
Sylvain de Rossi
Sunali Mehta
Serge Urbach
Jean-Christophe Bourdon
Pau Bernado
Andrey V. Kajava
Antony Braithwaite
Pierre Roux
Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
description p53 isoform Δ133p53β is reported to promote intrinsic oncogenic functions. Here the authors show Δ133p53β is sequestered as aggregates in an inactive form, while association with interacting partners including p63 isoforms and the CCT chaperone complex promotes Δ133p53β activity, resulting in enhanced cancer cell migration and invasion.
format article
author Nikola Arsic
Tania Slatter
Gilles Gadea
Etienne Villain
Aurelie Fournet
Marina Kazantseva
Frédéric Allemand
Nathalie Sibille
Martial Seveno
Sylvain de Rossi
Sunali Mehta
Serge Urbach
Jean-Christophe Bourdon
Pau Bernado
Andrey V. Kajava
Antony Braithwaite
Pierre Roux
author_facet Nikola Arsic
Tania Slatter
Gilles Gadea
Etienne Villain
Aurelie Fournet
Marina Kazantseva
Frédéric Allemand
Nathalie Sibille
Martial Seveno
Sylvain de Rossi
Sunali Mehta
Serge Urbach
Jean-Christophe Bourdon
Pau Bernado
Andrey V. Kajava
Antony Braithwaite
Pierre Roux
author_sort Nikola Arsic
title Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
title_short Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
title_full Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
title_fullStr Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
title_full_unstemmed Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
title_sort δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/68225466d9dc4ec1bb5844837f0a0ec8
work_keys_str_mv AT nikolaarsic d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT taniaslatter d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT gillesgadea d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT etiennevillain d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT aureliefournet d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT marinakazantseva d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT fredericallemand d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT nathaliesibille d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT martialseveno d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT sylvainderossi d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT sunalimehta d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT sergeurbach d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT jeanchristophebourdon d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT paubernado d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT andreyvkajava d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT antonybraithwaite d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
AT pierreroux d133p53bisoformproinvasiveactivityisregulatedthroughanaggregationdependentmechanismincancercells
_version_ 1718380974260092928