Laboratory monitoring of postvaccination measles immunity

Measles vaccination In Russian Federation was introduced in 1967. It was assumed that the twodose vaccination regime would lead to a decrease in the incidence and elimination of measles. A number of studies have shown that up to 10% of individuals who received two doses of measles vaccine do not dev...

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Autor principal:	A. A. Ereshchenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	measles immunity vaccination revaccination laboratory monitoring interindividual variability Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/682415df096049c5a9673f27e119d8ed
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spelling	oai:doaj.org-article:682415df096049c5a9673f27e119d8ed2021-11-18T08:03:49ZLaboratory monitoring of postvaccination measles immunity1563-06252313-741X10.15789/1563-0625-LMO-1876https://doaj.org/article/682415df096049c5a9673f27e119d8ed2020-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1876https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMeasles vaccination In Russian Federation was introduced in 1967. It was assumed that the twodose vaccination regime would lead to a decrease in the incidence and elimination of measles. A number of studies have shown that up to 10% of individuals who received two doses of measles vaccine do not develop a specific humoral immunity, or do not maintain it at a protective level. This fact may contribute to gradual accumulation of persons susceptible for measles infection in the population, thus leading to emergence of new viral outbreaks in the future. The aim of this study was to perform dynamic monitoring of the post-vaccination measles immunity. The study involved 149 people. All the examined persons were divided into 2 groups. The group of comparison included persons, aged 19 to 51 years, in whom absence of measles immunity was serologically confirmed (n = 76). This group was twice vaccinated with live measles culture vaccine (NPO “Microgen”, Russia). Determination of IgG to measles virus was carried out 1 month after vaccination and revaccination. The control group consisted of persons with documented evidence of double immunization against measles virus, with laboratory-confirmed measles immunity (n = 73), aged 19 to 53 years. The comparative dynamics of development and contents of antibodies in the comparison-control groups were considered, with respect to the WHO age classification. Basic and postvaccinal dynamic determination of IgG to measles virus in serum was performed by ELISA using the “VectoKor-IgG” test system (Vector-Best, Novosibirsk). When analyzing the results of the study, it was noted that the level of measles immunity group in older persons from control group (over 45 years old) was initially higher, than in younger subjects. Among young people, the titers of specific measles antibodies reached the values of the control group of the corresponding age after the first vaccination, whereas the level of specific measles antibodies in older age group was significantly lower compared to the control group even after revaccination. A month after the first immunization, 4 people did not reach the protective level of anti-measles IgG. However, revaccination allowed them to form anti-measles immunity. In the course of our work, a case of non-response to vaccination was identified. Thus, our study showed a sufficient interindividual variability in humoral immune responses to measles vaccination.A. A. EreshchenkoSPb RAACIarticlemeaslesimmunityvaccinationrevaccinationlaboratory monitoringinterindividual variabilityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 3, Pp 563-568 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	measles immunity vaccination revaccination laboratory monitoring interindividual variability Immunologic diseases. Allergy RC581-607
spellingShingle	measles immunity vaccination revaccination laboratory monitoring interindividual variability Immunologic diseases. Allergy RC581-607 A. A. Ereshchenko Laboratory monitoring of postvaccination measles immunity
description	Measles vaccination In Russian Federation was introduced in 1967. It was assumed that the twodose vaccination regime would lead to a decrease in the incidence and elimination of measles. A number of studies have shown that up to 10% of individuals who received two doses of measles vaccine do not develop a specific humoral immunity, or do not maintain it at a protective level. This fact may contribute to gradual accumulation of persons susceptible for measles infection in the population, thus leading to emergence of new viral outbreaks in the future. The aim of this study was to perform dynamic monitoring of the post-vaccination measles immunity. The study involved 149 people. All the examined persons were divided into 2 groups. The group of comparison included persons, aged 19 to 51 years, in whom absence of measles immunity was serologically confirmed (n = 76). This group was twice vaccinated with live measles culture vaccine (NPO “Microgen”, Russia). Determination of IgG to measles virus was carried out 1 month after vaccination and revaccination. The control group consisted of persons with documented evidence of double immunization against measles virus, with laboratory-confirmed measles immunity (n = 73), aged 19 to 53 years. The comparative dynamics of development and contents of antibodies in the comparison-control groups were considered, with respect to the WHO age classification. Basic and postvaccinal dynamic determination of IgG to measles virus in serum was performed by ELISA using the “VectoKor-IgG” test system (Vector-Best, Novosibirsk). When analyzing the results of the study, it was noted that the level of measles immunity group in older persons from control group (over 45 years old) was initially higher, than in younger subjects. Among young people, the titers of specific measles antibodies reached the values of the control group of the corresponding age after the first vaccination, whereas the level of specific measles antibodies in older age group was significantly lower compared to the control group even after revaccination. A month after the first immunization, 4 people did not reach the protective level of anti-measles IgG. However, revaccination allowed them to form anti-measles immunity. In the course of our work, a case of non-response to vaccination was identified. Thus, our study showed a sufficient interindividual variability in humoral immune responses to measles vaccination.
format	article
author	A. A. Ereshchenko
author_facet	A. A. Ereshchenko
author_sort	A. A. Ereshchenko
title	Laboratory monitoring of postvaccination measles immunity
title_short	Laboratory monitoring of postvaccination measles immunity
title_full	Laboratory monitoring of postvaccination measles immunity
title_fullStr	Laboratory monitoring of postvaccination measles immunity
title_full_unstemmed	Laboratory monitoring of postvaccination measles immunity
title_sort	laboratory monitoring of postvaccination measles immunity
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/682415df096049c5a9673f27e119d8ed
work_keys_str_mv	AT aaereshchenko laboratorymonitoringofpostvaccinationmeaslesimmunity
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Laboratory monitoring of postvaccination measles immunity

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