KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives

In this study, a novel approach has been used for the efficient synthesis of tetrahydrodipyrazolopyridine derivatives (5a–m) via a four-component one-pot condensation reaction of aromatic aldehydes, hydrazinehydrate, ethyl acetoacetate, and ammonium acetate in the presence of KCC-1-npr-NH2-DPA as an...

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Autores principales:	Sajjad Azizi, Nasrin Shadjou, Mohammad Hasanzadeh
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	dendritic fibrous nano-silica bioactive scaffold tetrahydrodipyrazolopyridines pharmaceutical compounds advanced functional materials Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/6824fcc9d5ce48f08db3fb70a35feb9b
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spelling	oai:doaj.org-article:6824fcc9d5ce48f08db3fb70a35feb9b2021-12-02T08:53:26ZKCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives2055-033210.1080/20550324.2019.1681623https://doaj.org/article/6824fcc9d5ce48f08db3fb70a35feb9b2019-10-01T00:00:00Zhttp://dx.doi.org/10.1080/20550324.2019.1681623https://doaj.org/toc/2055-0332In this study, a novel approach has been used for the efficient synthesis of tetrahydrodipyrazolopyridine derivatives (5a–m) via a four-component one-pot condensation reaction of aromatic aldehydes, hydrazinehydrate, ethyl acetoacetate, and ammonium acetate in the presence of KCC-1-npr-NH2-DPA as an advanced nano-catalyst in ethanol under reflux conditions at 30 min. For this purpose, mesoporous fibrous nano-silica functionalized by dipenicillamine as a novel nanocatalyst (KCC-1-npr-NH2-DPA) was synthesized using a hydrothermal protocol. KCC-1-npr-NH2-DPA nano-catalyst is easily recyclable eight times without the considerable loss of catalytic activity. Other remarkable features include the short reaction time, simple work-up procedure and providing excellent yields (89–98%) of the products under mild reaction conditions. Furthermore, the effects of solvent, concentration of catalyst, time and temperature for the synthesis of tetrahydrodipyrazolopyridine (5a) were studied.Sajjad AziziNasrin ShadjouMohammad HasanzadehTaylor & Francis Grouparticledendritic fibrous nano-silicabioactive scaffoldtetrahydrodipyrazolopyridinespharmaceutical compoundsadvanced functional materialsMaterials of engineering and construction. Mechanics of materialsTA401-492Polymers and polymer manufactureTP1080-1185ENNanocomposites, Vol 5, Iss 4, Pp 124-132 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	dendritic fibrous nano-silica bioactive scaffold tetrahydrodipyrazolopyridines pharmaceutical compounds advanced functional materials Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185
spellingShingle	dendritic fibrous nano-silica bioactive scaffold tetrahydrodipyrazolopyridines pharmaceutical compounds advanced functional materials Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185 Sajjad Azizi Nasrin Shadjou Mohammad Hasanzadeh KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives
description	In this study, a novel approach has been used for the efficient synthesis of tetrahydrodipyrazolopyridine derivatives (5a–m) via a four-component one-pot condensation reaction of aromatic aldehydes, hydrazinehydrate, ethyl acetoacetate, and ammonium acetate in the presence of KCC-1-npr-NH2-DPA as an advanced nano-catalyst in ethanol under reflux conditions at 30 min. For this purpose, mesoporous fibrous nano-silica functionalized by dipenicillamine as a novel nanocatalyst (KCC-1-npr-NH2-DPA) was synthesized using a hydrothermal protocol. KCC-1-npr-NH2-DPA nano-catalyst is easily recyclable eight times without the considerable loss of catalytic activity. Other remarkable features include the short reaction time, simple work-up procedure and providing excellent yields (89–98%) of the products under mild reaction conditions. Furthermore, the effects of solvent, concentration of catalyst, time and temperature for the synthesis of tetrahydrodipyrazolopyridine (5a) were studied.
format	article
author	Sajjad Azizi Nasrin Shadjou Mohammad Hasanzadeh
author_facet	Sajjad Azizi Nasrin Shadjou Mohammad Hasanzadeh
author_sort	Sajjad Azizi
title	KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives
title_short	KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives
title_full	KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives
title_fullStr	KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives
title_full_unstemmed	KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives
title_sort	kcc-1-nh2-dpa: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/6824fcc9d5ce48f08db3fb70a35feb9b
work_keys_str_mv	AT sajjadazizi kcc1nh2dpaanefficientheterogeneousrecyclablenanocompositeforthecatalyticsynthesisoftetrahydrodipyrazolopyridinesasawellknownorganicscaffoldinvariousbioactivederivatives AT nasrinshadjou kcc1nh2dpaanefficientheterogeneousrecyclablenanocompositeforthecatalyticsynthesisoftetrahydrodipyrazolopyridinesasawellknownorganicscaffoldinvariousbioactivederivatives AT mohammadhasanzadeh kcc1nh2dpaanefficientheterogeneousrecyclablenanocompositeforthecatalyticsynthesisoftetrahydrodipyrazolopyridinesasawellknownorganicscaffoldinvariousbioactivederivatives
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KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives

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