Oxidative Stress and Respiratory Diseases in Preterm Newborns

Premature infants are exposed to increased generation of reactive oxygen species, and on the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient part of lung injury that begins as acute inflammatory injury in respiratory distress disease and then evolves into...

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Autores principales:	Laura Cannavò, Serafina Perrone, Valeria Viola, Lucia Marseglia, Gabriella Di Rosa, Eloisa Gitto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oxidative stress preterm bronchopulmonary dysplasia respiratory distress syndrome pulmonary hypertension of the newborn Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/682aa510b3c44934adbf895d53a6223a
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spelling	oai:doaj.org-article:682aa510b3c44934adbf895d53a6223a2021-11-25T17:57:19ZOxidative Stress and Respiratory Diseases in Preterm Newborns10.3390/ijms2222125041422-00671661-6596https://doaj.org/article/682aa510b3c44934adbf895d53a6223a2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12504https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Premature infants are exposed to increased generation of reactive oxygen species, and on the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient part of lung injury that begins as acute inflammatory injury in respiratory distress disease and then evolves into chronic and structural scarring leading to bronchopulmonary dysplasia. Oxidative stress is also involved in the pathogenesis of pulmonary hypertension in newborns through the modulation of the vascular tone and the response to pulmonary vasodilators, with consequent decrease in the density of the pulmonary vessels and thickening of the pulmonary arteriolar walls. Oxidative stress has been recognized as both a trigger and an endpoint for several events, including inflammation, hypoxia, hyperoxia, drugs, transfusions, and mechanical ventilation, with impairment of pulmonary function and prolonged lung damage. Redoxomics is the most fascinating new measure to address lung damage due to oxidative stress. The new challenge is to use omics data to discover a set of biomarkers useful in diagnosis, prognosis, and formulating optimal and individualized neonatal care. The aim of this review was to examine the most recent evidence on the relationship between oxidative stress and lung diseases in preterm newborns. What is currently known regarding oxidative stress-related lung injury pathogenesis and the available preventive and therapeutic strategies are also discussed.Laura CannavòSerafina PerroneValeria ViolaLucia MarsegliaGabriella Di RosaEloisa GittoMDPI AGarticleoxidative stresspretermbronchopulmonary dysplasiarespiratory distress syndromepulmonary hypertension of the newbornBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12504, p 12504 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress preterm bronchopulmonary dysplasia respiratory distress syndrome pulmonary hypertension of the newborn Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	oxidative stress preterm bronchopulmonary dysplasia respiratory distress syndrome pulmonary hypertension of the newborn Biology (General) QH301-705.5 Chemistry QD1-999 Laura Cannavò Serafina Perrone Valeria Viola Lucia Marseglia Gabriella Di Rosa Eloisa Gitto Oxidative Stress and Respiratory Diseases in Preterm Newborns
description	Premature infants are exposed to increased generation of reactive oxygen species, and on the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient part of lung injury that begins as acute inflammatory injury in respiratory distress disease and then evolves into chronic and structural scarring leading to bronchopulmonary dysplasia. Oxidative stress is also involved in the pathogenesis of pulmonary hypertension in newborns through the modulation of the vascular tone and the response to pulmonary vasodilators, with consequent decrease in the density of the pulmonary vessels and thickening of the pulmonary arteriolar walls. Oxidative stress has been recognized as both a trigger and an endpoint for several events, including inflammation, hypoxia, hyperoxia, drugs, transfusions, and mechanical ventilation, with impairment of pulmonary function and prolonged lung damage. Redoxomics is the most fascinating new measure to address lung damage due to oxidative stress. The new challenge is to use omics data to discover a set of biomarkers useful in diagnosis, prognosis, and formulating optimal and individualized neonatal care. The aim of this review was to examine the most recent evidence on the relationship between oxidative stress and lung diseases in preterm newborns. What is currently known regarding oxidative stress-related lung injury pathogenesis and the available preventive and therapeutic strategies are also discussed.
format	article
author	Laura Cannavò Serafina Perrone Valeria Viola Lucia Marseglia Gabriella Di Rosa Eloisa Gitto
author_facet	Laura Cannavò Serafina Perrone Valeria Viola Lucia Marseglia Gabriella Di Rosa Eloisa Gitto
author_sort	Laura Cannavò
title	Oxidative Stress and Respiratory Diseases in Preterm Newborns
title_short	Oxidative Stress and Respiratory Diseases in Preterm Newborns
title_full	Oxidative Stress and Respiratory Diseases in Preterm Newborns
title_fullStr	Oxidative Stress and Respiratory Diseases in Preterm Newborns
title_full_unstemmed	Oxidative Stress and Respiratory Diseases in Preterm Newborns
title_sort	oxidative stress and respiratory diseases in preterm newborns
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/682aa510b3c44934adbf895d53a6223a
work_keys_str_mv	AT lauracannavo oxidativestressandrespiratorydiseasesinpretermnewborns AT serafinaperrone oxidativestressandrespiratorydiseasesinpretermnewborns AT valeriaviola oxidativestressandrespiratorydiseasesinpretermnewborns AT luciamarseglia oxidativestressandrespiratorydiseasesinpretermnewborns AT gabrielladirosa oxidativestressandrespiratorydiseasesinpretermnewborns AT eloisagitto oxidativestressandrespiratorydiseasesinpretermnewborns
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Oxidative Stress and Respiratory Diseases in Preterm Newborns

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