Traffic air pollution and oxidized LDL.

<h4>Background</h4>Epidemiologic studies indirectly suggest that air pollution accelerates atherosclerosis. We hypothesized that individual exposure to particulate matter (PM) derived from fossil fuel would correlate with plasma concentrations of oxidized low-density lipoprotein (LDL), t...

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Autores principales:	Lotte Jacobs, Jan Emmerechts, Marc F Hoylaerts, Chantal Mathieu, Peter H Hoet, Benoit Nemery, Tim S Nawrot
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/682aab1ee5394e44bb301f92551986f0
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spelling	oai:doaj.org-article:682aab1ee5394e44bb301f92551986f02021-11-18T07:00:15ZTraffic air pollution and oxidized LDL.1932-620310.1371/journal.pone.0016200https://doaj.org/article/682aab1ee5394e44bb301f92551986f02011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21283820/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Epidemiologic studies indirectly suggest that air pollution accelerates atherosclerosis. We hypothesized that individual exposure to particulate matter (PM) derived from fossil fuel would correlate with plasma concentrations of oxidized low-density lipoprotein (LDL), taken as a marker of atherosclerosis. We tested this hypothesis in patients with diabetes, who are at high risk for atherosclerosis.<h4>Methodology/principal findings</h4>In a cross-sectional study of non-smoking adult outpatients with diabetes we assessed individual chronic exposure to PM by measuring the area occupied by carbon in airway macrophages, collected by sputum induction and by determining the distance from the patient's residence to a major road, through geocoding. These exposure indices were regressed against plasma concentrations of oxidized LDL, von Willebrand factor and plasminogen activator inhibitor 1 (PAI-1). We could assess the carbon load of airway macrophages in 79 subjects (58 percent). Each doubling in the distance of residence from major roads was associated with a 0.027 µm(2) decrease (95% confidence interval (CI): -0.048 to -0.0051) in the carbon load of airway macrophages. Independently from other covariates, we found that each increase of 0.25 µm(2) [interquartile range (IQR)] in carbon load was associated with an increase of 7.3 U/L (95% CI: 1.3 to 13.3) in plasma oxidized LDL. Each doubling in distance of residence from major roads was associated with a decrease of -2.9 U/L (95% CI: -5.2 to -0.72) in oxidized LDL. Neither the carbon load of macrophages nor the distance from residence to major roads, were associated with plasma von Willebrand factor or PAI-1.<h4>Conclusions</h4>The observed positive association, in a susceptible group of the general population, between plasma oxidized LDL levels and either the carbon load of airway macrophages or the proximity of the subject's residence to busy roads suggests a proatherogenic effect of traffic air pollution.Lotte JacobsJan EmmerechtsMarc F HoylaertsChantal MathieuPeter H HoetBenoit NemeryTim S NawrotPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e16200 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lotte Jacobs Jan Emmerechts Marc F Hoylaerts Chantal Mathieu Peter H Hoet Benoit Nemery Tim S Nawrot Traffic air pollution and oxidized LDL.
description	<h4>Background</h4>Epidemiologic studies indirectly suggest that air pollution accelerates atherosclerosis. We hypothesized that individual exposure to particulate matter (PM) derived from fossil fuel would correlate with plasma concentrations of oxidized low-density lipoprotein (LDL), taken as a marker of atherosclerosis. We tested this hypothesis in patients with diabetes, who are at high risk for atherosclerosis.<h4>Methodology/principal findings</h4>In a cross-sectional study of non-smoking adult outpatients with diabetes we assessed individual chronic exposure to PM by measuring the area occupied by carbon in airway macrophages, collected by sputum induction and by determining the distance from the patient's residence to a major road, through geocoding. These exposure indices were regressed against plasma concentrations of oxidized LDL, von Willebrand factor and plasminogen activator inhibitor 1 (PAI-1). We could assess the carbon load of airway macrophages in 79 subjects (58 percent). Each doubling in the distance of residence from major roads was associated with a 0.027 µm(2) decrease (95% confidence interval (CI): -0.048 to -0.0051) in the carbon load of airway macrophages. Independently from other covariates, we found that each increase of 0.25 µm(2) [interquartile range (IQR)] in carbon load was associated with an increase of 7.3 U/L (95% CI: 1.3 to 13.3) in plasma oxidized LDL. Each doubling in distance of residence from major roads was associated with a decrease of -2.9 U/L (95% CI: -5.2 to -0.72) in oxidized LDL. Neither the carbon load of macrophages nor the distance from residence to major roads, were associated with plasma von Willebrand factor or PAI-1.<h4>Conclusions</h4>The observed positive association, in a susceptible group of the general population, between plasma oxidized LDL levels and either the carbon load of airway macrophages or the proximity of the subject's residence to busy roads suggests a proatherogenic effect of traffic air pollution.
format	article
author	Lotte Jacobs Jan Emmerechts Marc F Hoylaerts Chantal Mathieu Peter H Hoet Benoit Nemery Tim S Nawrot
author_facet	Lotte Jacobs Jan Emmerechts Marc F Hoylaerts Chantal Mathieu Peter H Hoet Benoit Nemery Tim S Nawrot
author_sort	Lotte Jacobs
title	Traffic air pollution and oxidized LDL.
title_short	Traffic air pollution and oxidized LDL.
title_full	Traffic air pollution and oxidized LDL.
title_fullStr	Traffic air pollution and oxidized LDL.
title_full_unstemmed	Traffic air pollution and oxidized LDL.
title_sort	traffic air pollution and oxidized ldl.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/682aab1ee5394e44bb301f92551986f0
work_keys_str_mv	AT lottejacobs trafficairpollutionandoxidizedldl AT janemmerechts trafficairpollutionandoxidizedldl AT marcfhoylaerts trafficairpollutionandoxidizedldl AT chantalmathieu trafficairpollutionandoxidizedldl AT peterhhoet trafficairpollutionandoxidizedldl AT benoitnemery trafficairpollutionandoxidizedldl AT timsnawrot trafficairpollutionandoxidizedldl
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Traffic air pollution and oxidized LDL.

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