Options for Synthetic DNA Order Screening, Revisited

ABSTRACT Gene synthesis providers affiliated with the International Gene Synthesis Consortium (IGSC) voluntarily screen double-stranded DNA (dsDNA) synthesis orders over 200 bp to check for matches to regulated pathogens and to screen customers. Questions have been raised, however, about the continu...

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Autores principales:	Diane DiEuliis, Sarah R. Carter, Gigi Kwik Gronvall
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	biosecurity science policy synthetic biology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/682f974db32c460998ab7e11ede71450
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spelling	oai:doaj.org-article:682f974db32c460998ab7e11ede714502021-11-15T15:22:05ZOptions for Synthetic DNA Order Screening, Revisited10.1128/mSphere.00319-172379-5042https://doaj.org/article/682f974db32c460998ab7e11ede714502017-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00319-17https://doaj.org/toc/2379-5042ABSTRACT Gene synthesis providers affiliated with the International Gene Synthesis Consortium (IGSC) voluntarily screen double-stranded DNA (dsDNA) synthesis orders over 200 bp to check for matches to regulated pathogens and to screen customers. Questions have been raised, however, about the continuing feasibility and effectiveness of screening. There are technical challenges (e.g., oligonucleotides and tracts of DNA less than 200 bp are not screened) and corporate challenges (e.g., the costs of screening are high, but other costs are dropping, so screening is an increasing portion of operating costs). In this article, we describe tangible actions that should be taken to (i) preserve the effectiveness of DNA order screening as a security tool and (ii) develop additional mechanisms to increase the safety and security of DNA synthesis technologies. Screening is not a perfect solution to DNA synthesis security challenges, but we believe it is still a valuable addition to security, and it can remain effective for some time.Diane DiEuliisSarah R. CarterGigi Kwik GronvallAmerican Society for Microbiologyarticlebiosecurityscience policysynthetic biologyMicrobiologyQR1-502ENmSphere, Vol 2, Iss 4 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	biosecurity science policy synthetic biology Microbiology QR1-502
spellingShingle	biosecurity science policy synthetic biology Microbiology QR1-502 Diane DiEuliis Sarah R. Carter Gigi Kwik Gronvall Options for Synthetic DNA Order Screening, Revisited
description	ABSTRACT Gene synthesis providers affiliated with the International Gene Synthesis Consortium (IGSC) voluntarily screen double-stranded DNA (dsDNA) synthesis orders over 200 bp to check for matches to regulated pathogens and to screen customers. Questions have been raised, however, about the continuing feasibility and effectiveness of screening. There are technical challenges (e.g., oligonucleotides and tracts of DNA less than 200 bp are not screened) and corporate challenges (e.g., the costs of screening are high, but other costs are dropping, so screening is an increasing portion of operating costs). In this article, we describe tangible actions that should be taken to (i) preserve the effectiveness of DNA order screening as a security tool and (ii) develop additional mechanisms to increase the safety and security of DNA synthesis technologies. Screening is not a perfect solution to DNA synthesis security challenges, but we believe it is still a valuable addition to security, and it can remain effective for some time.
format	article
author	Diane DiEuliis Sarah R. Carter Gigi Kwik Gronvall
author_facet	Diane DiEuliis Sarah R. Carter Gigi Kwik Gronvall
author_sort	Diane DiEuliis
title	Options for Synthetic DNA Order Screening, Revisited
title_short	Options for Synthetic DNA Order Screening, Revisited
title_full	Options for Synthetic DNA Order Screening, Revisited
title_fullStr	Options for Synthetic DNA Order Screening, Revisited
title_full_unstemmed	Options for Synthetic DNA Order Screening, Revisited
title_sort	options for synthetic dna order screening, revisited
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/682f974db32c460998ab7e11ede71450
work_keys_str_mv	AT dianedieuliis optionsforsyntheticdnaorderscreeningrevisited AT sarahrcarter optionsforsyntheticdnaorderscreeningrevisited AT gigikwikgronvall optionsforsyntheticdnaorderscreeningrevisited
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Options for Synthetic DNA Order Screening, Revisited

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