A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity
Abstract Cytokines play a critical role in the pathogenesis and development of cardiovascular diseases. However, data linking cytokines to risk and severity of acute coronary syndrome (ACS) are still limited. We measured plasma profile of 280 cytokines using a quantitative protein microarray in 12 A...
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2019
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oai:doaj.org-article:6830eb5cf199405485ddfbff6c1d2fc72021-12-02T15:09:58ZA multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity10.1038/s41598-019-41577-42045-2322https://doaj.org/article/6830eb5cf199405485ddfbff6c1d2fc72019-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-41577-4https://doaj.org/toc/2045-2322Abstract Cytokines play a critical role in the pathogenesis and development of cardiovascular diseases. However, data linking cytokines to risk and severity of acute coronary syndrome (ACS) are still limited. We measured plasma profile of 280 cytokines using a quantitative protein microarray in 12 ACS patients and 16 healthy controls, and identified 15 differentially expressed cytokines for ACS. Osteopontin, chemokine ligand 23, brain derived neurotrophic factor and C-reactive protein (CRP) were further validated using immunoassay in two independent case-control studies with a total of 210 ACS patients and 210 controls. We further examined their relations with incident ACS among 318 case-control pairs nested within the Dongfeng-Tongji cohort, and found plasma osteopontin and CRP concentrations were associated with incident ACS, and the multivariable-adjusted odds ratio (95% confidence interval) was 1.29 (1.06–1.57) per 1-SD increase for osteopontin and 1.30 (1.02–1.66) for CRP, respectively. Higher levels of circulating osteopontin were also correlated with higher severity of ACS, and earlier ACS onset time. Adding osteopontin alone or in combination with CRP modestly improved the predictive ability of ACS beyond the Framingham risk scores. Our findings suggested that osteopontin might be a biomarker for incident ACS, using osteopontin adds moderately to traditional cardiovascular risk factors.Kuai YuBinyao YangHaijing JiangJun LiKai YanXuezhen LiuLue ZhouHandong YangXiulou LiXinwen MinCe ZhangXiaoting LuoWenhua MeiShunchang SunLiyun ZhangXiang ChengMeian HeXiaomin ZhangAn PanFrank B. HuTangchun WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) |
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Medicine R Science Q |
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Medicine R Science Q Kuai Yu Binyao Yang Haijing Jiang Jun Li Kai Yan Xuezhen Liu Lue Zhou Handong Yang Xiulou Li Xinwen Min Ce Zhang Xiaoting Luo Wenhua Mei Shunchang Sun Liyun Zhang Xiang Cheng Meian He Xiaomin Zhang An Pan Frank B. Hu Tangchun Wu A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity |
| description |
Abstract Cytokines play a critical role in the pathogenesis and development of cardiovascular diseases. However, data linking cytokines to risk and severity of acute coronary syndrome (ACS) are still limited. We measured plasma profile of 280 cytokines using a quantitative protein microarray in 12 ACS patients and 16 healthy controls, and identified 15 differentially expressed cytokines for ACS. Osteopontin, chemokine ligand 23, brain derived neurotrophic factor and C-reactive protein (CRP) were further validated using immunoassay in two independent case-control studies with a total of 210 ACS patients and 210 controls. We further examined their relations with incident ACS among 318 case-control pairs nested within the Dongfeng-Tongji cohort, and found plasma osteopontin and CRP concentrations were associated with incident ACS, and the multivariable-adjusted odds ratio (95% confidence interval) was 1.29 (1.06–1.57) per 1-SD increase for osteopontin and 1.30 (1.02–1.66) for CRP, respectively. Higher levels of circulating osteopontin were also correlated with higher severity of ACS, and earlier ACS onset time. Adding osteopontin alone or in combination with CRP modestly improved the predictive ability of ACS beyond the Framingham risk scores. Our findings suggested that osteopontin might be a biomarker for incident ACS, using osteopontin adds moderately to traditional cardiovascular risk factors. |
| format |
article |
| author |
Kuai Yu Binyao Yang Haijing Jiang Jun Li Kai Yan Xuezhen Liu Lue Zhou Handong Yang Xiulou Li Xinwen Min Ce Zhang Xiaoting Luo Wenhua Mei Shunchang Sun Liyun Zhang Xiang Cheng Meian He Xiaomin Zhang An Pan Frank B. Hu Tangchun Wu |
| author_facet |
Kuai Yu Binyao Yang Haijing Jiang Jun Li Kai Yan Xuezhen Liu Lue Zhou Handong Yang Xiulou Li Xinwen Min Ce Zhang Xiaoting Luo Wenhua Mei Shunchang Sun Liyun Zhang Xiang Cheng Meian He Xiaomin Zhang An Pan Frank B. Hu Tangchun Wu |
| author_sort |
Kuai Yu |
| title |
A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity |
| title_short |
A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity |
| title_full |
A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity |
| title_fullStr |
A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity |
| title_full_unstemmed |
A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity |
| title_sort |
multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/6830eb5cf199405485ddfbff6c1d2fc7 |
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