A meta-analysis of Prognostic factor of Pancreatic neuroendocrine neoplasms

Abstract Pancreatic neuroendocrine neoplasms (pNENs) are a group of clinically rare and heterogeneous diseases of the pancreas. However, the prognostic factors for this disease in patients still remain controversial. The purpose of our study is to evaluate the predictive roles of those prognostic fa...

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Autores principales:	Yong Gao, Hao Gao, Guangfu Wang, Lingdi Yin, Wenbin Xu, Yunpeng Peng, Junli Wu, Kuirong Jiang, Yi Miao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68332daf5aa045cf84662b03793c34be
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spelling	oai:doaj.org-article:68332daf5aa045cf84662b03793c34be2021-12-02T11:40:34ZA meta-analysis of Prognostic factor of Pancreatic neuroendocrine neoplasms10.1038/s41598-018-24072-02045-2322https://doaj.org/article/68332daf5aa045cf84662b03793c34be2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24072-0https://doaj.org/toc/2045-2322Abstract Pancreatic neuroendocrine neoplasms (pNENs) are a group of clinically rare and heterogeneous diseases of the pancreas. However, the prognostic factors for this disease in patients still remain controversial. The purpose of our study is to evaluate the predictive roles of those prognostic factors for pNENs. All related articles published until Sep 17, 2017 were identified via PubMed, EMBASE, Web of Science, Ovid and the Cochrane Library. Studies that examined the prognostic factors of pNENs were enrolled. 17 articles (2822 patients) were finally included in this study. The pooled data suggested that patients with positive surgical resection margin and lymph node, advanced G stage and TMN stage, organ metastasis, vascular invasion and the necrosis of specimens had a decreased overall survival for pNENs. Similarly, patients with functional tumors might have a poor prognosis. However, age, gender, surgical type and size of tumor could not be regarded as prognostic factors for pNENs. Our analytic data demonstrated that surgical resection margin, G stage, TMN stage, lymph node, metastasis, vascular invasion and the necrosis could be prognostic factors for pNENs. Our study may assist doctors to screen patients with different prognosis more efficiently during follow-up and select appropriate treatment measures.Yong GaoHao GaoGuangfu WangLingdi YinWenbin XuYunpeng PengJunli WuKuirong JiangYi MiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Gao Hao Gao Guangfu Wang Lingdi Yin Wenbin Xu Yunpeng Peng Junli Wu Kuirong Jiang Yi Miao A meta-analysis of Prognostic factor of Pancreatic neuroendocrine neoplasms
description	Abstract Pancreatic neuroendocrine neoplasms (pNENs) are a group of clinically rare and heterogeneous diseases of the pancreas. However, the prognostic factors for this disease in patients still remain controversial. The purpose of our study is to evaluate the predictive roles of those prognostic factors for pNENs. All related articles published until Sep 17, 2017 were identified via PubMed, EMBASE, Web of Science, Ovid and the Cochrane Library. Studies that examined the prognostic factors of pNENs were enrolled. 17 articles (2822 patients) were finally included in this study. The pooled data suggested that patients with positive surgical resection margin and lymph node, advanced G stage and TMN stage, organ metastasis, vascular invasion and the necrosis of specimens had a decreased overall survival for pNENs. Similarly, patients with functional tumors might have a poor prognosis. However, age, gender, surgical type and size of tumor could not be regarded as prognostic factors for pNENs. Our analytic data demonstrated that surgical resection margin, G stage, TMN stage, lymph node, metastasis, vascular invasion and the necrosis could be prognostic factors for pNENs. Our study may assist doctors to screen patients with different prognosis more efficiently during follow-up and select appropriate treatment measures.
format	article
author	Yong Gao Hao Gao Guangfu Wang Lingdi Yin Wenbin Xu Yunpeng Peng Junli Wu Kuirong Jiang Yi Miao
author_facet	Yong Gao Hao Gao Guangfu Wang Lingdi Yin Wenbin Xu Yunpeng Peng Junli Wu Kuirong Jiang Yi Miao
author_sort	Yong Gao
title	A meta-analysis of Prognostic factor of Pancreatic neuroendocrine neoplasms
title_short	A meta-analysis of Prognostic factor of Pancreatic neuroendocrine neoplasms
title_full	A meta-analysis of Prognostic factor of Pancreatic neuroendocrine neoplasms
title_fullStr	A meta-analysis of Prognostic factor of Pancreatic neuroendocrine neoplasms
title_full_unstemmed	A meta-analysis of Prognostic factor of Pancreatic neuroendocrine neoplasms
title_sort	meta-analysis of prognostic factor of pancreatic neuroendocrine neoplasms
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/68332daf5aa045cf84662b03793c34be
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A meta-analysis of Prognostic factor of Pancreatic neuroendocrine neoplasms

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