Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma

Abstract Although differentiation between central chondroid tumors is important, their parallelism makes it a diagnostic conundrum for clinicians and radiologists. The objective of this study was to evaluate the efficiency of quantitative single photon emission computed tomography (SPECT)/computed t...

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Autores principales:	Woo Hee Choi, Eun Ji Han, Ki Bong Chang, Min Wook Joo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/683779cad2184aeebf73a70cdc6dc17d
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spelling	oai:doaj.org-article:683779cad2184aeebf73a70cdc6dc17d2021-12-02T16:31:46ZQuantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma10.1038/s41598-020-67506-42045-2322https://doaj.org/article/683779cad2184aeebf73a70cdc6dc17d2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-67506-4https://doaj.org/toc/2045-2322Abstract Although differentiation between central chondroid tumors is important, their parallelism makes it a diagnostic conundrum for clinicians and radiologists. The objective of this study was to evaluate the efficiency of quantitative single photon emission computed tomography (SPECT)/computed tomography (CT) in differentiating grade I chondrosarcomas from enchondromas. We reviewed SPECT/CT images of patients with enchondromas and grade I chondrosarcomas arising in the long bones. Volume, mean standardized uptake value (SUVmean), and maximum standardized uptake value (SUVmax) of tumors were calculated from SPECT/CT images. In addition, clinical characteristics and radiological information were assessed. Of a total of 34 patients, 14 had chondrosarcomas. Chondrosarcoma group had significantly larger volume, and higher SUVmean and SUVmax of tumors than enchondroma group. There was no significant difference in age and tumor size between two groups. Areas under the receiver-operating characteristic curve (AUCs) for tumor volume, SUVmean, and SUVmax were 0.727, 0.757, and 0.875. In pairwise analyses, SUVmax had larger AUC than SUVmean (p = 0.0216). With a cut-off value of 15.6 for SUVmax, its sensitivity and specificity were 86% and 75% for differentiating between enchondroma and grade I chondrosarcoma. Quantitative SPECT/CT is a potential method to differentiate grade I chondroarcomas from enchondromas in patients with central chondroid tumors.Woo Hee ChoiEun Ji HanKi Bong ChangMin Wook JooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Woo Hee Choi Eun Ji Han Ki Bong Chang Min Wook Joo Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma
description	Abstract Although differentiation between central chondroid tumors is important, their parallelism makes it a diagnostic conundrum for clinicians and radiologists. The objective of this study was to evaluate the efficiency of quantitative single photon emission computed tomography (SPECT)/computed tomography (CT) in differentiating grade I chondrosarcomas from enchondromas. We reviewed SPECT/CT images of patients with enchondromas and grade I chondrosarcomas arising in the long bones. Volume, mean standardized uptake value (SUVmean), and maximum standardized uptake value (SUVmax) of tumors were calculated from SPECT/CT images. In addition, clinical characteristics and radiological information were assessed. Of a total of 34 patients, 14 had chondrosarcomas. Chondrosarcoma group had significantly larger volume, and higher SUVmean and SUVmax of tumors than enchondroma group. There was no significant difference in age and tumor size between two groups. Areas under the receiver-operating characteristic curve (AUCs) for tumor volume, SUVmean, and SUVmax were 0.727, 0.757, and 0.875. In pairwise analyses, SUVmax had larger AUC than SUVmean (p = 0.0216). With a cut-off value of 15.6 for SUVmax, its sensitivity and specificity were 86% and 75% for differentiating between enchondroma and grade I chondrosarcoma. Quantitative SPECT/CT is a potential method to differentiate grade I chondroarcomas from enchondromas in patients with central chondroid tumors.
format	article
author	Woo Hee Choi Eun Ji Han Ki Bong Chang Min Wook Joo
author_facet	Woo Hee Choi Eun Ji Han Ki Bong Chang Min Wook Joo
author_sort	Woo Hee Choi
title	Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma
title_short	Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma
title_full	Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma
title_fullStr	Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma
title_full_unstemmed	Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma
title_sort	quantitative spect/ct for differentiating between enchondroma and grade i chondrosarcoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/683779cad2184aeebf73a70cdc6dc17d
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Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma

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