Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials

Einar Furulund,1– 3 Mitra Bemanian,2,3 Nina Berggren,3 Tesfaye Madebo,2,4 Sara Hydle Rivedal,3 Torgeir Gilje Lid,1,5 Lars Thore Fadnes2,3 1Centre for Alcohol and Drug Research, Stavanger University Hospital, Stavanger, Norway; 2Bergen Addiction Research, Department of Addiction Medicine, Haukeland U...

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Autores principales:	Furulund E, Bemanian M, Berggren N, Madebo T, Rivedal SH, Lid TG, Fadnes LT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	nutrition lung function inflammation physical function health-related quality of life Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/6838e3674300420ab5b70742bfb4450d
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spelling	oai:doaj.org-article:6838e3674300420ab5b70742bfb4450d2021-11-18T19:40:25ZEffects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials1178-2005https://doaj.org/article/6838e3674300420ab5b70742bfb4450d2021-11-01T00:00:00Zhttps://www.dovepress.com/effects-of-nutritional-interventions-in-individuals-with-chronic-obstr-peer-reviewed-fulltext-article-COPDhttps://doaj.org/toc/1178-2005Einar Furulund,1– 3 Mitra Bemanian,2,3 Nina Berggren,3 Tesfaye Madebo,2,4 Sara Hydle Rivedal,3 Torgeir Gilje Lid,1,5 Lars Thore Fadnes2,3 1Centre for Alcohol and Drug Research, Stavanger University Hospital, Stavanger, Norway; 2Bergen Addiction Research, Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway; 3Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; 4Department of Respiratory Medicine, Stavanger University Hospital, Stavanger, Norway; 5Department of Public Health, University of Stavanger, Stavanger, NorwayCorrespondence: Einar FurulundCentre for Alcohol and Drug Research, Stavanger University Hospital, Stavanger, NorwayTel +4751518000Email Einar.Furulund@sus.noBackground: The role of nutrition and dietary patterns has been widely investigated in cancer, cardiovascular disease, and diabetes, but there are limited data on nutritional impact on COPD. This systematic review (PROSPERO-reg. no: CRD42020172712) aimed to investigate the effect of nutritional interventions on pulmonary and physical function, inflammation, and health-related quality of life among individuals with COPD.Methods: Systematic searches were conducted in Medline, Embase, and Cochrane, resulting in 3861 references. Studies focusing exclusively on inpatient-stays, underweight or obese patients were excluded. Double screening, extraction and bias assessment were conducted. Bias was assessed according to the Cochrane risk of bias tool for randomized controlled trials. Thirteen randomized controlled trials with 916 participants were included.Results: These trials investigated effects of protein supplementation, beetroot juice, increased fruit and vegetable intake, black seed oil, Tualang honey, Chlorella vulgaris-extract, whey-peptide containing nutritional drink, and increased macronutrient intake. The durations of the interventions were from weeks to a few months, and only one with duration > 1 year (investigating increased fruit/vegetable intake). The intervention increasing fruit/vegetables found improvement in pulmonary function tests. Some interventions observed effects on systemic inflammation, health-related quality of life and physical function, although with some mixed results. Five were classified as poor, five as fair, and three as good in terms of risk of bias and quality.Conclusion: Increasing intake of fruits and vegetables over prolonged periods might have positive effects on lung function in individuals with COPD. Some nutritional interventions also observed effects on systemic inflammation, health-related quality of life, and physical function, although with some mixed results. Many of the trials were underpowered, had high dropout rates, or had a high risk of bias. Further research should investigate effect of prolonged dietary interventions.Keywords: nutrition, lung function, inflammation, physical function, health-related quality of lifeFurulund EBemanian MBerggren NMadebo TRivedal SHLid TGFadnes LTDove Medical Pressarticlenutritionlung functioninflammationphysical functionhealth-related quality of lifeDiseases of the respiratory systemRC705-779ENInternational Journal of COPD, Vol Volume 16, Pp 3145-3156 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nutrition lung function inflammation physical function health-related quality of life Diseases of the respiratory system RC705-779
spellingShingle	nutrition lung function inflammation physical function health-related quality of life Diseases of the respiratory system RC705-779 Furulund E Bemanian M Berggren N Madebo T Rivedal SH Lid TG Fadnes LT Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials
description	Einar Furulund,1– 3 Mitra Bemanian,2,3 Nina Berggren,3 Tesfaye Madebo,2,4 Sara Hydle Rivedal,3 Torgeir Gilje Lid,1,5 Lars Thore Fadnes2,3 1Centre for Alcohol and Drug Research, Stavanger University Hospital, Stavanger, Norway; 2Bergen Addiction Research, Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway; 3Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; 4Department of Respiratory Medicine, Stavanger University Hospital, Stavanger, Norway; 5Department of Public Health, University of Stavanger, Stavanger, NorwayCorrespondence: Einar FurulundCentre for Alcohol and Drug Research, Stavanger University Hospital, Stavanger, NorwayTel +4751518000Email Einar.Furulund@sus.noBackground: The role of nutrition and dietary patterns has been widely investigated in cancer, cardiovascular disease, and diabetes, but there are limited data on nutritional impact on COPD. This systematic review (PROSPERO-reg. no: CRD42020172712) aimed to investigate the effect of nutritional interventions on pulmonary and physical function, inflammation, and health-related quality of life among individuals with COPD.Methods: Systematic searches were conducted in Medline, Embase, and Cochrane, resulting in 3861 references. Studies focusing exclusively on inpatient-stays, underweight or obese patients were excluded. Double screening, extraction and bias assessment were conducted. Bias was assessed according to the Cochrane risk of bias tool for randomized controlled trials. Thirteen randomized controlled trials with 916 participants were included.Results: These trials investigated effects of protein supplementation, beetroot juice, increased fruit and vegetable intake, black seed oil, Tualang honey, Chlorella vulgaris-extract, whey-peptide containing nutritional drink, and increased macronutrient intake. The durations of the interventions were from weeks to a few months, and only one with duration > 1 year (investigating increased fruit/vegetable intake). The intervention increasing fruit/vegetables found improvement in pulmonary function tests. Some interventions observed effects on systemic inflammation, health-related quality of life and physical function, although with some mixed results. Five were classified as poor, five as fair, and three as good in terms of risk of bias and quality.Conclusion: Increasing intake of fruits and vegetables over prolonged periods might have positive effects on lung function in individuals with COPD. Some nutritional interventions also observed effects on systemic inflammation, health-related quality of life, and physical function, although with some mixed results. Many of the trials were underpowered, had high dropout rates, or had a high risk of bias. Further research should investigate effect of prolonged dietary interventions.Keywords: nutrition, lung function, inflammation, physical function, health-related quality of life
format	article
author	Furulund E Bemanian M Berggren N Madebo T Rivedal SH Lid TG Fadnes LT
author_facet	Furulund E Bemanian M Berggren N Madebo T Rivedal SH Lid TG Fadnes LT
author_sort	Furulund E
title	Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials
title_short	Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials
title_full	Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials
title_fullStr	Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials
title_full_unstemmed	Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials
title_sort	effects of nutritional interventions in individuals with chronic obstructive lung disease: a systematic review of randomized controlled trials
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6838e3674300420ab5b70742bfb4450d
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Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials

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