Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain

To better understand the complexity of clock genes in salmonids, a taxon with an additional whole genome duplication, an analysis was performed to identify and classify gene family members (clock, arntl, period, cryptochrome, nr1d, ror, and csnk1). The majority of clock genes, in zebrafish and North...

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Autores principales:	Charlotte M. Bolton, Michaël Bekaert, Mariann Eilertsen, Jon Vidar Helvik, Herve Migaud
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	clock genes ohnologs circadian whole-genome duplication rhythmic expression Physiology QP1-981
Acceso en línea:	https://doaj.org/article/683c207488874832bf86121a0295f99b
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id	oai:doaj.org-article:683c207488874832bf86121a0295f99b
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spelling	oai:doaj.org-article:683c207488874832bf86121a0295f99b2021-12-02T10:20:44ZRhythmic Clock Gene Expression in Atlantic Salmon Parr Brain1664-042X10.3389/fphys.2021.761109https://doaj.org/article/683c207488874832bf86121a0295f99b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.761109/fullhttps://doaj.org/toc/1664-042XTo better understand the complexity of clock genes in salmonids, a taxon with an additional whole genome duplication, an analysis was performed to identify and classify gene family members (clock, arntl, period, cryptochrome, nr1d, ror, and csnk1). The majority of clock genes, in zebrafish and Northern pike, appeared to be duplicated. In comparison to the 29 clock genes described in zebrafish, 48 clock genes were discovered in salmonid species. There was also evidence of species-specific reciprocal gene losses conserved to the Oncorhynchus sister clade. From the six period genes identified three were highly significantly rhythmic, and circadian in their expression patterns (per1a.1, per1a.2, per1b) and two was significantly rhythmically expressed (per2a, per2b). The transcriptomic study of juvenile Atlantic salmon (parr) brain tissues confirmed gene identification and revealed that there were 2,864 rhythmically expressed genes (p < 0.001), including 1,215 genes with a circadian expression pattern, of which 11 were clock genes. The majority of circadian expressed genes peaked 2 h before and after daylight. These findings provide a foundation for further research into the function of clock genes circadian rhythmicity and the role of an enriched number of clock genes relating to seasonal driven life history in salmonids.Charlotte M. BoltonMichaël BekaertMariann EilertsenJon Vidar HelvikHerve MigaudFrontiers Media S.A.articleclock genesohnologscircadianwhole-genome duplicationrhythmic expressionPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clock genes ohnologs circadian whole-genome duplication rhythmic expression Physiology QP1-981
spellingShingle	clock genes ohnologs circadian whole-genome duplication rhythmic expression Physiology QP1-981 Charlotte M. Bolton Michaël Bekaert Mariann Eilertsen Jon Vidar Helvik Herve Migaud Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain
description	To better understand the complexity of clock genes in salmonids, a taxon with an additional whole genome duplication, an analysis was performed to identify and classify gene family members (clock, arntl, period, cryptochrome, nr1d, ror, and csnk1). The majority of clock genes, in zebrafish and Northern pike, appeared to be duplicated. In comparison to the 29 clock genes described in zebrafish, 48 clock genes were discovered in salmonid species. There was also evidence of species-specific reciprocal gene losses conserved to the Oncorhynchus sister clade. From the six period genes identified three were highly significantly rhythmic, and circadian in their expression patterns (per1a.1, per1a.2, per1b) and two was significantly rhythmically expressed (per2a, per2b). The transcriptomic study of juvenile Atlantic salmon (parr) brain tissues confirmed gene identification and revealed that there were 2,864 rhythmically expressed genes (p < 0.001), including 1,215 genes with a circadian expression pattern, of which 11 were clock genes. The majority of circadian expressed genes peaked 2 h before and after daylight. These findings provide a foundation for further research into the function of clock genes circadian rhythmicity and the role of an enriched number of clock genes relating to seasonal driven life history in salmonids.
format	article
author	Charlotte M. Bolton Michaël Bekaert Mariann Eilertsen Jon Vidar Helvik Herve Migaud
author_facet	Charlotte M. Bolton Michaël Bekaert Mariann Eilertsen Jon Vidar Helvik Herve Migaud
author_sort	Charlotte M. Bolton
title	Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain
title_short	Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain
title_full	Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain
title_fullStr	Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain
title_full_unstemmed	Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain
title_sort	rhythmic clock gene expression in atlantic salmon parr brain
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/683c207488874832bf86121a0295f99b
work_keys_str_mv	AT charlottembolton rhythmicclockgeneexpressioninatlanticsalmonparrbrain AT michaelbekaert rhythmicclockgeneexpressioninatlanticsalmonparrbrain AT marianneilertsen rhythmicclockgeneexpressioninatlanticsalmonparrbrain AT jonvidarhelvik rhythmicclockgeneexpressioninatlanticsalmonparrbrain AT hervemigaud rhythmicclockgeneexpressioninatlanticsalmonparrbrain
_version_	1718397410729787392

Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain

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