Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm

Myomerger mediates the transition from the early hemifusion stage to complete fusion during the formation of multinucleated muscle cells. Here, authors use theoretical modeling and cell fusion experiments to show that Myomerger promotes a fusion pore by coupling the elastic stresses of the proximal...

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Autores principales: Gonen Golani, Evgenia Leikina, Kamran Melikov, Jarred M. Whitlock, Dilani G. Gamage, Gracia Luoma-Overstreet, Douglas P. Millay, Michael M. Kozlov, Leonid V. Chernomordik
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/683f78c9584c4f6da8fc976af9832ff6
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Sumario:Myomerger mediates the transition from the early hemifusion stage to complete fusion during the formation of multinucleated muscle cells. Here, authors use theoretical modeling and cell fusion experiments to show that Myomerger promotes a fusion pore by coupling the elastic stresses of the proximal and distal leaflets of myoblast membrane.