Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm

Myomerger mediates the transition from the early hemifusion stage to complete fusion during the formation of multinucleated muscle cells. Here, authors use theoretical modeling and cell fusion experiments to show that Myomerger promotes a fusion pore by coupling the elastic stresses of the proximal...

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Main Authors:	Gonen Golani, Evgenia Leikina, Kamran Melikov, Jarred M. Whitlock, Dilani G. Gamage, Gracia Luoma-Overstreet, Douglas P. Millay, Michael M. Kozlov, Leonid V. Chernomordik
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/683f78c9584c4f6da8fc976af9832ff6
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spelling	oai:doaj.org-article:683f78c9584c4f6da8fc976af9832ff62021-12-02T10:49:21ZMyomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm10.1038/s41467-020-20804-x2041-1723https://doaj.org/article/683f78c9584c4f6da8fc976af9832ff62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20804-xhttps://doaj.org/toc/2041-1723Myomerger mediates the transition from the early hemifusion stage to complete fusion during the formation of multinucleated muscle cells. Here, authors use theoretical modeling and cell fusion experiments to show that Myomerger promotes a fusion pore by coupling the elastic stresses of the proximal and distal leaflets of myoblast membrane.Gonen GolaniEvgenia LeikinaKamran MelikovJarred M. WhitlockDilani G. GamageGracia Luoma-OverstreetDouglas P. MillayMichael M. KozlovLeonid V. ChernomordikNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gonen Golani Evgenia Leikina Kamran Melikov Jarred M. Whitlock Dilani G. Gamage Gracia Luoma-Overstreet Douglas P. Millay Michael M. Kozlov Leonid V. Chernomordik Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm
description	Myomerger mediates the transition from the early hemifusion stage to complete fusion during the formation of multinucleated muscle cells. Here, authors use theoretical modeling and cell fusion experiments to show that Myomerger promotes a fusion pore by coupling the elastic stresses of the proximal and distal leaflets of myoblast membrane.
format	article
author	Gonen Golani Evgenia Leikina Kamran Melikov Jarred M. Whitlock Dilani G. Gamage Gracia Luoma-Overstreet Douglas P. Millay Michael M. Kozlov Leonid V. Chernomordik
author_facet	Gonen Golani Evgenia Leikina Kamran Melikov Jarred M. Whitlock Dilani G. Gamage Gracia Luoma-Overstreet Douglas P. Millay Michael M. Kozlov Leonid V. Chernomordik
author_sort	Gonen Golani
title	Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm
title_short	Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm
title_full	Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm
title_fullStr	Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm
title_full_unstemmed	Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm
title_sort	myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/683f78c9584c4f6da8fc976af9832ff6
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Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm

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