NIR responsive liposomal system for rapid release of drugs in cancer therapy

Ming-Mao Chen,1 Yuan-Yuan Liu,1 Guang-Hao Su,2 Fei-Fei Song,1 Yan Liu,3 Qi-Qing Zhang1,4 1Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 2Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, 3State Key Lab of Structural Che...

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Autores principales:	Chen MM, Liu YY, Su GH, Song FF, Liu Y, Zhang QQ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	NIR responsive thermoresponsive liposome triggered drug release bubble-generating thermo-chemotherapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/683f7901c2fc4a2b8501ac59fbd034bc
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spelling	oai:doaj.org-article:683f7901c2fc4a2b8501ac59fbd034bc2021-12-02T05:15:17ZNIR responsive liposomal system for rapid release of drugs in cancer therapy1178-2013https://doaj.org/article/683f7901c2fc4a2b8501ac59fbd034bc2017-06-01T00:00:00Zhttps://www.dovepress.com/nir-responsive-liposomal-system-for-rapid-release-of-drugs-in-cancer-t-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ming-Mao Chen,1 Yuan-Yuan Liu,1 Guang-Hao Su,2 Fei-Fei Song,1 Yan Liu,3 Qi-Qing Zhang1,4 1Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 2Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, 3State Key Lab of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 4Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, People’s Republic of China Abstract: To design a rapid release liposomal system for cancer therapy, a NIR responsive bubble-generating thermosensitive liposome (BTSL) system combined with photothermal agent (Cypate), doxorubicin (DOX), and NH4HCO3 was developed. Cypate/DOX-BTSL exhibited a good aqueous stability, photostability, and photothermal effect. In vitro release suggested that the amounts of DOX released from BTSL were obviously higher than that of (NH4)2SO4 liposomes at 42°C. After NIR irradiation, the hyperthermic temperature induced by Cypate led to the decomposition of NH4HCO3 and the generation of a large number of CO2 bubbles, triggering a rapid release of drugs. Confocal laser scanning microscope and acridine orange staining indicated that Cypate/DOX-BTSL upon irradiation could facilitate to disrupt the lysosomal membranes and realize endolysosomal escape into cytosol, improving the intracellular uptake of DOX clearly. MTT and trypan blue staining implied that the cell damage of Cypate/DOX-BTSL with NIR irradiation was more severe than that in the groups without irradiation. In vivo results indicated that Cypate/DOX-BTSL with irradiation could dramatically increase the accumulation of DOX in tumor, inhibit tumor growth, and reduce systemic side effects of DOX. These data demonstrated that Cypate/DOX-BTSL has the potential to be used as a NIR responsive liposomal system for a rapid release of drugs in thermochemotherapy. Keywords: NIR responsive, thermoresponsive liposome, triggered drug release, bubble-generating, thermochemotherapyChen MMLiu YYSu GHSong FFLiu YZhang QQDove Medical PressarticleNIR responsivethermoresponsive liposometriggered drug releasebubble-generatingthermo-chemotherapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4225-4239 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	NIR responsive thermoresponsive liposome triggered drug release bubble-generating thermo-chemotherapy Medicine (General) R5-920
spellingShingle	NIR responsive thermoresponsive liposome triggered drug release bubble-generating thermo-chemotherapy Medicine (General) R5-920 Chen MM Liu YY Su GH Song FF Liu Y Zhang QQ NIR responsive liposomal system for rapid release of drugs in cancer therapy
description	Ming-Mao Chen,1 Yuan-Yuan Liu,1 Guang-Hao Su,2 Fei-Fei Song,1 Yan Liu,3 Qi-Qing Zhang1,4 1Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, 2Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, 3State Key Lab of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 4Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, People’s Republic of China Abstract: To design a rapid release liposomal system for cancer therapy, a NIR responsive bubble-generating thermosensitive liposome (BTSL) system combined with photothermal agent (Cypate), doxorubicin (DOX), and NH4HCO3 was developed. Cypate/DOX-BTSL exhibited a good aqueous stability, photostability, and photothermal effect. In vitro release suggested that the amounts of DOX released from BTSL were obviously higher than that of (NH4)2SO4 liposomes at 42°C. After NIR irradiation, the hyperthermic temperature induced by Cypate led to the decomposition of NH4HCO3 and the generation of a large number of CO2 bubbles, triggering a rapid release of drugs. Confocal laser scanning microscope and acridine orange staining indicated that Cypate/DOX-BTSL upon irradiation could facilitate to disrupt the lysosomal membranes and realize endolysosomal escape into cytosol, improving the intracellular uptake of DOX clearly. MTT and trypan blue staining implied that the cell damage of Cypate/DOX-BTSL with NIR irradiation was more severe than that in the groups without irradiation. In vivo results indicated that Cypate/DOX-BTSL with irradiation could dramatically increase the accumulation of DOX in tumor, inhibit tumor growth, and reduce systemic side effects of DOX. These data demonstrated that Cypate/DOX-BTSL has the potential to be used as a NIR responsive liposomal system for a rapid release of drugs in thermochemotherapy. Keywords: NIR responsive, thermoresponsive liposome, triggered drug release, bubble-generating, thermochemotherapy
format	article
author	Chen MM Liu YY Su GH Song FF Liu Y Zhang QQ
author_facet	Chen MM Liu YY Su GH Song FF Liu Y Zhang QQ
author_sort	Chen MM
title	NIR responsive liposomal system for rapid release of drugs in cancer therapy
title_short	NIR responsive liposomal system for rapid release of drugs in cancer therapy
title_full	NIR responsive liposomal system for rapid release of drugs in cancer therapy
title_fullStr	NIR responsive liposomal system for rapid release of drugs in cancer therapy
title_full_unstemmed	NIR responsive liposomal system for rapid release of drugs in cancer therapy
title_sort	nir responsive liposomal system for rapid release of drugs in cancer therapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/683f7901c2fc4a2b8501ac59fbd034bc
work_keys_str_mv	AT chenmm nirresponsiveliposomalsystemforrapidreleaseofdrugsincancertherapy AT liuyy nirresponsiveliposomalsystemforrapidreleaseofdrugsincancertherapy AT sugh nirresponsiveliposomalsystemforrapidreleaseofdrugsincancertherapy AT songff nirresponsiveliposomalsystemforrapidreleaseofdrugsincancertherapy AT liuy nirresponsiveliposomalsystemforrapidreleaseofdrugsincancertherapy AT zhangqq nirresponsiveliposomalsystemforrapidreleaseofdrugsincancertherapy
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NIR responsive liposomal system for rapid release of drugs in cancer therapy

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