Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats

Yanyan Zhou,1 Zihe Hu,1 Mingjie Ge,1 Wenjing Jin,1 Ruikang Tang,2 Qi Li,1 Weijian Xu,1 Jue Shi,1 Zhijian Xie1 1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Resea...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhou Y, Hu Z, Ge M, Jin W, Tang R, Li Q, Xu W, Shi J, Xie Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	polymer induced liquid-precursor calcium phosphates nanocluster osteoporosis oral implant Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/684347c7f15a4cedaf1a22a20fc70629
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:684347c7f15a4cedaf1a22a20fc70629
record_format	dspace
spelling	oai:doaj.org-article:684347c7f15a4cedaf1a22a20fc706292021-12-02T17:37:48ZIntraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats1178-2013https://doaj.org/article/684347c7f15a4cedaf1a22a20fc706292021-09-01T00:00:00Zhttps://www.dovepress.com/intraosseous-injection-of-calcium-phosphate-polymer-induced-liquid-pre-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Yanyan Zhou,1 Zihe Hu,1 Mingjie Ge,1 Wenjing Jin,1 Ruikang Tang,2 Qi Li,1 Weijian Xu,1 Jue Shi,1 Zhijian Xie1 1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, People’s Republic of China; 2Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, 310027, People’s Republic of ChinaCorrespondence: Zhijian Xie; Jue Shi Email xzj66@zju.edu.cn; dentistsj@zju.edu.cnPurpose: Osteoporosis, due to bone loss and structural deterioration, is a risk factor for dental implant failure, as it impedes initial stability and osseointegration. We aim to assess the effects of calcium phosphate polymer-induced liquid precursor (CaP-PILP) treatment, which significantly increases bone density and improves early implant osseointegration in ovariectomized rats.Methods: In this study, CaP-PILP was synthesized and characterized through TEM, FTIR and XRD. A rat model of osteoporosis was generated by ovariectomy. CaP-PILP or hydroxyapatite (HAP, negative control) was injected into the tibia, and the resulting changes in bone quality were determined. Further, implants were installed in the treated tibias, and implantation characteristics were assessed after 4 weeks.Results: The CaP-PILP group had superior bone repair. Importantly, CaP-PILP had excellent properties, similar to those of normal bone, in terms of implant osseointegration. In vivo experiment displayed that CaP-PILP group had better bone contact rate (65.97± 3.176) than HAP and OVX groups. Meanwhile, a mound of mature and continuous new bone formed. Moreover, the values of BIC and BA showed no significant difference between the CaP-PILP group and the sham group.Conclusion: In summary, CaP-PILP is a promising material for application in poor-quality bones to improve implant success rates in patients with osteoporosis. This research provides new perspectives on the application of nano-apatite materials in bone repair.Keywords: polymer-induced liquid precursor, calcium phosphates, nanocluster, osteoporosis, oral implantZhou YHu ZGe MJin WTang RLi QXu WShi JXie ZDove Medical Pressarticlepolymer induced liquid-precursorcalcium phosphatesnanoclusterosteoporosisoral implantMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 6217-6229 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymer induced liquid-precursor calcium phosphates nanocluster osteoporosis oral implant Medicine (General) R5-920
spellingShingle	polymer induced liquid-precursor calcium phosphates nanocluster osteoporosis oral implant Medicine (General) R5-920 Zhou Y Hu Z Ge M Jin W Tang R Li Q Xu W Shi J Xie Z Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats
description	Yanyan Zhou,1 Zihe Hu,1 Mingjie Ge,1 Wenjing Jin,1 Ruikang Tang,2 Qi Li,1 Weijian Xu,1 Jue Shi,1 Zhijian Xie1 1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, People’s Republic of China; 2Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, 310027, People’s Republic of ChinaCorrespondence: Zhijian Xie; Jue Shi Email xzj66@zju.edu.cn; dentistsj@zju.edu.cnPurpose: Osteoporosis, due to bone loss and structural deterioration, is a risk factor for dental implant failure, as it impedes initial stability and osseointegration. We aim to assess the effects of calcium phosphate polymer-induced liquid precursor (CaP-PILP) treatment, which significantly increases bone density and improves early implant osseointegration in ovariectomized rats.Methods: In this study, CaP-PILP was synthesized and characterized through TEM, FTIR and XRD. A rat model of osteoporosis was generated by ovariectomy. CaP-PILP or hydroxyapatite (HAP, negative control) was injected into the tibia, and the resulting changes in bone quality were determined. Further, implants were installed in the treated tibias, and implantation characteristics were assessed after 4 weeks.Results: The CaP-PILP group had superior bone repair. Importantly, CaP-PILP had excellent properties, similar to those of normal bone, in terms of implant osseointegration. In vivo experiment displayed that CaP-PILP group had better bone contact rate (65.97± 3.176) than HAP and OVX groups. Meanwhile, a mound of mature and continuous new bone formed. Moreover, the values of BIC and BA showed no significant difference between the CaP-PILP group and the sham group.Conclusion: In summary, CaP-PILP is a promising material for application in poor-quality bones to improve implant success rates in patients with osteoporosis. This research provides new perspectives on the application of nano-apatite materials in bone repair.Keywords: polymer-induced liquid precursor, calcium phosphates, nanocluster, osteoporosis, oral implant
format	article
author	Zhou Y Hu Z Ge M Jin W Tang R Li Q Xu W Shi J Xie Z
author_facet	Zhou Y Hu Z Ge M Jin W Tang R Li Q Xu W Shi J Xie Z
author_sort	Zhou Y
title	Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats
title_short	Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats
title_full	Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats
title_fullStr	Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats
title_full_unstemmed	Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats
title_sort	intraosseous injection of calcium phosphate polymer-induced liquid precursor increases bone density and improves early implant osseointegration in ovariectomized rats
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/684347c7f15a4cedaf1a22a20fc70629
work_keys_str_mv	AT zhouy intraosseousinjectionofcalciumphosphatepolymerinducedliquidprecursorincreasesbonedensityandimprovesearlyimplantosseointegrationinovariectomizedrats AT huz intraosseousinjectionofcalciumphosphatepolymerinducedliquidprecursorincreasesbonedensityandimprovesearlyimplantosseointegrationinovariectomizedrats AT gem intraosseousinjectionofcalciumphosphatepolymerinducedliquidprecursorincreasesbonedensityandimprovesearlyimplantosseointegrationinovariectomizedrats AT jinw intraosseousinjectionofcalciumphosphatepolymerinducedliquidprecursorincreasesbonedensityandimprovesearlyimplantosseointegrationinovariectomizedrats AT tangr intraosseousinjectionofcalciumphosphatepolymerinducedliquidprecursorincreasesbonedensityandimprovesearlyimplantosseointegrationinovariectomizedrats AT liq intraosseousinjectionofcalciumphosphatepolymerinducedliquidprecursorincreasesbonedensityandimprovesearlyimplantosseointegrationinovariectomizedrats AT xuw intraosseousinjectionofcalciumphosphatepolymerinducedliquidprecursorincreasesbonedensityandimprovesearlyimplantosseointegrationinovariectomizedrats AT shij intraosseousinjectionofcalciumphosphatepolymerinducedliquidprecursorincreasesbonedensityandimprovesearlyimplantosseointegrationinovariectomizedrats AT xiez intraosseousinjectionofcalciumphosphatepolymerinducedliquidprecursorincreasesbonedensityandimprovesearlyimplantosseointegrationinovariectomizedrats
_version_	1718379826668109824

Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats

Ejemplares similares