Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan

Acute and advanced heart failure are associated with substantial adverse short- and longer-term prognosis. Both conditions necessitate complex treatment choices to restore haemodynamic stability and organ perfusion, relieve congestion, improve symptoms and allow the patient to leave the hospital and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Piergiuseppe Agostoni, Dimitrios T Farmakis, Jose M García-Pinilla, Veli-Pekka Harjola, Kristjan Karason, Dirk von Lewinski, John Parissis, Piero Pollesello, Gerhard Pölzl, Alejandro Recio-Mayoral, Alexander Reinecke, Patrik Yerly, Endre Zima
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/6844d16cafb94c2091be95085b31eb55
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6844d16cafb94c2091be95085b31eb55
record_format	dspace
spelling	oai:doaj.org-article:6844d16cafb94c2091be95085b31eb552021-12-04T16:01:51ZHaemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan10.15420/cfr.2019.01.R12057-75592057-7540https://doaj.org/article/6844d16cafb94c2091be95085b31eb552019-11-01T00:00:00Zhttps://www.cfrjournal.com/articles/Haemodynamic-Balance-Heart-Failure-Role-of-Levosimendanhttps://doaj.org/toc/2057-7540https://doaj.org/toc/2057-7559Acute and advanced heart failure are associated with substantial adverse short- and longer-term prognosis. Both conditions necessitate complex treatment choices to restore haemodynamic stability and organ perfusion, relieve congestion, improve symptoms and allow the patient to leave the hospital and achieve an adequate quality of life. Among the available intravenous vasoactive therapies, inotropes constitute an option when an increase in cardiac contractility is needed to reverse a low output state. Within the inotrope category, levosimendan is well suited to the needs of both sets of patients since, in contrast to conventional adrenergic inotropes, it has not been linked in clinical trials or wider clinical usage with increased mortality risk and retains its efficacy in the presence of beta-adrenergic receptor blockade; it is further believed to possess beneficial renal effects. The overall haemodynamic profile and clinical tolerability of levosimendan, combined with its extended duration of action, have encouraged its intermittent use in patients with advanced heart failure. This paper summarises the key messages derived from a series of 12 tutorials held at the Heart Failure 2019 congress organised in Athens, Greece, by the Heart Failure Association of the European Society of Cardiology.Piergiuseppe AgostoniDimitrios T FarmakisJose M García-PinillaVeli-Pekka HarjolaKristjan KarasonDirk von LewinskiJohn ParissisPiero PolleselloGerhard PölzlAlejandro Recio-MayoralAlexander ReineckePatrik YerlyEndre ZimaRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiac Failure Review , Vol 5, Iss 3, Pp 155-161 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Piergiuseppe Agostoni Dimitrios T Farmakis Jose M García-Pinilla Veli-Pekka Harjola Kristjan Karason Dirk von Lewinski John Parissis Piero Pollesello Gerhard Pölzl Alejandro Recio-Mayoral Alexander Reinecke Patrik Yerly Endre Zima Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan
description	Acute and advanced heart failure are associated with substantial adverse short- and longer-term prognosis. Both conditions necessitate complex treatment choices to restore haemodynamic stability and organ perfusion, relieve congestion, improve symptoms and allow the patient to leave the hospital and achieve an adequate quality of life. Among the available intravenous vasoactive therapies, inotropes constitute an option when an increase in cardiac contractility is needed to reverse a low output state. Within the inotrope category, levosimendan is well suited to the needs of both sets of patients since, in contrast to conventional adrenergic inotropes, it has not been linked in clinical trials or wider clinical usage with increased mortality risk and retains its efficacy in the presence of beta-adrenergic receptor blockade; it is further believed to possess beneficial renal effects. The overall haemodynamic profile and clinical tolerability of levosimendan, combined with its extended duration of action, have encouraged its intermittent use in patients with advanced heart failure. This paper summarises the key messages derived from a series of 12 tutorials held at the Heart Failure 2019 congress organised in Athens, Greece, by the Heart Failure Association of the European Society of Cardiology.
format	article
author	Piergiuseppe Agostoni Dimitrios T Farmakis Jose M García-Pinilla Veli-Pekka Harjola Kristjan Karason Dirk von Lewinski John Parissis Piero Pollesello Gerhard Pölzl Alejandro Recio-Mayoral Alexander Reinecke Patrik Yerly Endre Zima
author_facet	Piergiuseppe Agostoni Dimitrios T Farmakis Jose M García-Pinilla Veli-Pekka Harjola Kristjan Karason Dirk von Lewinski John Parissis Piero Pollesello Gerhard Pölzl Alejandro Recio-Mayoral Alexander Reinecke Patrik Yerly Endre Zima
author_sort	Piergiuseppe Agostoni
title	Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan
title_short	Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan
title_full	Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan
title_fullStr	Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan
title_full_unstemmed	Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan
title_sort	haemodynamic balance in acute and advanced heart failure: an expert perspective on the role of levosimendan
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/6844d16cafb94c2091be95085b31eb55
work_keys_str_mv	AT piergiuseppeagostoni haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT dimitriostfarmakis haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT josemgarciapinilla haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT velipekkaharjola haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT kristjankarason haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT dirkvonlewinski haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT johnparissis haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT pieropollesello haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT gerhardpolzl haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT alejandroreciomayoral haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT alexanderreinecke haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT patrikyerly haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan AT endrezima haemodynamicbalanceinacuteandadvancedheartfailureanexpertperspectiveontheroleoflevosimendan
_version_	1718372740146135040

Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan

Ejemplares similares