Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.

Mycobacterium avium subsp. paratuberculosis (MAP) infection is highly spread in the ruminant herds of Sardinia, in the Western Mediterranean. The objective of this study was to investigate prevalence of MAP infection in association with Multiple Sclerosis (MS) using clinical specimen from patients a...

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Autores principales:	Davide Cossu, Eleonora Cocco, Daniela Paccagnini, Speranza Masala, Niyaz Ahmed, Jessica Frau, Maria Giovanna Marrosu, Leonardo A Sechi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68468178b7b046edab3e6881517a0960
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spelling	oai:doaj.org-article:68468178b7b046edab3e6881517a09602021-11-18T06:55:50ZAssociation of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.1932-620310.1371/journal.pone.0018482https://doaj.org/article/68468178b7b046edab3e6881517a09602011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21533236/?tool=EBIhttps://doaj.org/toc/1932-6203Mycobacterium avium subsp. paratuberculosis (MAP) infection is highly spread in the ruminant herds of Sardinia, in the Western Mediterranean. The objective of this study was to investigate prevalence of MAP infection in association with Multiple Sclerosis (MS) using clinical specimen from patients and controls. We analyzed samples for the presence of MAP specific DNA and to demonstrate humoral response to a MAP protein (MAP2694), a predicted homologue of the T-cell receptor gamma-chain/complement component 1 of the host. We found presence of MAP DNA in 42% of the MS patients and an extremely significant humoral immune response revealed by the MS patients against the MAP protein. In our opinion, this is the first report that significantly associates MAP infection with MS. Further studies will be required to confirm if MAP could be one of the triggers of MS, according to the molecular mimicry theory, in susceptible (and genetically at risk) individuals.Davide CossuEleonora CoccoDaniela PaccagniniSperanza MasalaNiyaz AhmedJessica FrauMaria Giovanna MarrosuLeonardo A SechiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18482 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Davide Cossu Eleonora Cocco Daniela Paccagnini Speranza Masala Niyaz Ahmed Jessica Frau Maria Giovanna Marrosu Leonardo A Sechi Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.
description	Mycobacterium avium subsp. paratuberculosis (MAP) infection is highly spread in the ruminant herds of Sardinia, in the Western Mediterranean. The objective of this study was to investigate prevalence of MAP infection in association with Multiple Sclerosis (MS) using clinical specimen from patients and controls. We analyzed samples for the presence of MAP specific DNA and to demonstrate humoral response to a MAP protein (MAP2694), a predicted homologue of the T-cell receptor gamma-chain/complement component 1 of the host. We found presence of MAP DNA in 42% of the MS patients and an extremely significant humoral immune response revealed by the MS patients against the MAP protein. In our opinion, this is the first report that significantly associates MAP infection with MS. Further studies will be required to confirm if MAP could be one of the triggers of MS, according to the molecular mimicry theory, in susceptible (and genetically at risk) individuals.
format	article
author	Davide Cossu Eleonora Cocco Daniela Paccagnini Speranza Masala Niyaz Ahmed Jessica Frau Maria Giovanna Marrosu Leonardo A Sechi
author_facet	Davide Cossu Eleonora Cocco Daniela Paccagnini Speranza Masala Niyaz Ahmed Jessica Frau Maria Giovanna Marrosu Leonardo A Sechi
author_sort	Davide Cossu
title	Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.
title_short	Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.
title_full	Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.
title_fullStr	Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.
title_full_unstemmed	Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.
title_sort	association of mycobacterium avium subsp. paratuberculosis with multiple sclerosis in sardinian patients.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/68468178b7b046edab3e6881517a0960
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Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients.

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