Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility

Beibei Hu,1,2 Jianxin Wang,3 Jing Li,3 Sanming Li,3 Heran Li1 1School of Pharmacy, China Medical University, Shenyang 110122, People’s Republic of China; 2College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’...

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Autores principales:	Hu B, Wang J, Li J, Li S, Li H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	chiral mesoporous silica carboxyl modification wettability bio-adhesion biocompatibility Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6848f2eebdb34a69b92042d924576fcc
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spelling	oai:doaj.org-article:6848f2eebdb34a69b92042d924576fcc2021-12-02T09:15:34ZSuperiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility1178-2013https://doaj.org/article/6848f2eebdb34a69b92042d924576fcc2020-01-01T00:00:00Zhttps://www.dovepress.com/superiority-of-l-tartaric-acid-modified-chiral-mesoporous-silica-nanop-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Beibei Hu,1,2 Jianxin Wang,3 Jing Li,3 Sanming Li,3 Heran Li1 1School of Pharmacy, China Medical University, Shenyang 110122, People’s Republic of China; 2College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’s Republic of China; 3School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaCorrespondence: Heran LiSchool of Pharmacy, China Medical University, 77 Puhe Road, Shenyang North New Area, Shenyang 110122, People’s Republic of ChinaTel +86 13897945866Email liheranmm@163.comPurpose: The purpose of this research was to study the basic physicochemical and biological properties regarding the application of L-tartaric acid modified chiral mesoporous silica nanoparticle (CMSN) as a drug carrier, and to explore the structure–property relationship of silica-based materials.Methods: CMSN with functions of carboxyl modification and chirality was successfully synthesized through co-condensation method, and the basic characteristics of CMSN, including morphology, structure, wettability, degradation, bio-adhesion and retention ability in gastrointestinal tract (GI tract) were estimated by comparing with non-functionalized mesoporous silica nanoparticles (MSN). Meanwhile, the biocompatibility and toxicity of L-tartaric modification were systematically evaluated both in vitro and in vivo through MTT cell viability assay, cell cycle and apoptosis assay, hemolysis assay, histopathology examination, hematology analysis, and clinical chemistry examination.Results: CMSN and MSN were spherical nanoparticles with uniform mesoporous structure. CMSN with smaller pore size and carboxyl functional groups exhibited better wettability. Besides, CMSN and MSN could dissolve thoroughly in simulated physiological fluids during a degradation period of 1– 12 weeks. Interestingly, the in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion and retention ability in the GI tract were closely related to wettability. As expected, CMSN had faster degradation rate, higher mucosa-adhesion ability, and longer retention time. Particularly, CMSN improved the bio-adhesion property in both gastric mucosa and small intestinal mucosa, and prolonged the GI tract retention time to at least 12 h, which meant higher probability for absorption. The biocompatibility and toxicity examination indicated that CMSN was a kind of biocompatible bio-material with good blood compatibility and negligible toxicity, which is required for further applications in biological fields.Conclusion: CMSN with functions of carboxyl modification and chirality had superiority in terms of both physicochemical and biological properties. The in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion, and retention were closely related to wettability.Keywords: chiral mesoporous silica, carboxyl modification, wettability, bio-adhesion, biocompatibilityHu BWang JLi JLi SLi HDove Medical Pressarticlechiral mesoporous silicacarboxyl modificationwettabilitybio-adhesionbiocompatibilityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 601-618 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	chiral mesoporous silica carboxyl modification wettability bio-adhesion biocompatibility Medicine (General) R5-920
spellingShingle	chiral mesoporous silica carboxyl modification wettability bio-adhesion biocompatibility Medicine (General) R5-920 Hu B Wang J Li J Li S Li H Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility
description	Beibei Hu,1,2 Jianxin Wang,3 Jing Li,3 Sanming Li,3 Heran Li1 1School of Pharmacy, China Medical University, Shenyang 110122, People’s Republic of China; 2College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’s Republic of China; 3School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaCorrespondence: Heran LiSchool of Pharmacy, China Medical University, 77 Puhe Road, Shenyang North New Area, Shenyang 110122, People’s Republic of ChinaTel +86 13897945866Email liheranmm@163.comPurpose: The purpose of this research was to study the basic physicochemical and biological properties regarding the application of L-tartaric acid modified chiral mesoporous silica nanoparticle (CMSN) as a drug carrier, and to explore the structure–property relationship of silica-based materials.Methods: CMSN with functions of carboxyl modification and chirality was successfully synthesized through co-condensation method, and the basic characteristics of CMSN, including morphology, structure, wettability, degradation, bio-adhesion and retention ability in gastrointestinal tract (GI tract) were estimated by comparing with non-functionalized mesoporous silica nanoparticles (MSN). Meanwhile, the biocompatibility and toxicity of L-tartaric modification were systematically evaluated both in vitro and in vivo through MTT cell viability assay, cell cycle and apoptosis assay, hemolysis assay, histopathology examination, hematology analysis, and clinical chemistry examination.Results: CMSN and MSN were spherical nanoparticles with uniform mesoporous structure. CMSN with smaller pore size and carboxyl functional groups exhibited better wettability. Besides, CMSN and MSN could dissolve thoroughly in simulated physiological fluids during a degradation period of 1– 12 weeks. Interestingly, the in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion and retention ability in the GI tract were closely related to wettability. As expected, CMSN had faster degradation rate, higher mucosa-adhesion ability, and longer retention time. Particularly, CMSN improved the bio-adhesion property in both gastric mucosa and small intestinal mucosa, and prolonged the GI tract retention time to at least 12 h, which meant higher probability for absorption. The biocompatibility and toxicity examination indicated that CMSN was a kind of biocompatible bio-material with good blood compatibility and negligible toxicity, which is required for further applications in biological fields.Conclusion: CMSN with functions of carboxyl modification and chirality had superiority in terms of both physicochemical and biological properties. The in vitro and in vivo behaviors of carriers, including degradation, bio-adhesion, and retention were closely related to wettability.Keywords: chiral mesoporous silica, carboxyl modification, wettability, bio-adhesion, biocompatibility
format	article
author	Hu B Wang J Li J Li S Li H
author_facet	Hu B Wang J Li J Li S Li H
author_sort	Hu B
title	Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility
title_short	Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility
title_full	Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility
title_fullStr	Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility
title_full_unstemmed	Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility
title_sort	superiority of l-tartaric acid modified chiral mesoporous silica nanoparticle as a drug carrier: structure, wettability, degradation, bio-adhesion and biocompatibility
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/6848f2eebdb34a69b92042d924576fcc
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Superiority of L-tartaric Acid Modified Chiral Mesoporous Silica Nanoparticle as a Drug Carrier: Structure, Wettability, Degradation, Bio-Adhesion and Biocompatibility

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