Improvement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity

Sevda Karimian,1 Juergen Stein,2 Boris Bauer,3 Claudius Teupe1 1Department of Medicine – Cardiology, 2Department of Medicine – Gastroenterology, 3Department of Radiology, Krankenhaus Sachsenhausen, Teaching Hospital of Goethe University Frankfurt, Frankfurt, Germany Back...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Karimian S, Stein J, Bauer B, Teupe C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	obesity echocardiography tissue Doppler imaging diastolic function weight loss Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/6851684d63a146f299c321b1d7c98568
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6851684d63a146f299c321b1d7c98568
record_format	dspace
spelling	oai:doaj.org-article:6851684d63a146f299c321b1d7c985682021-12-02T05:17:59ZImprovement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity1178-7007https://doaj.org/article/6851684d63a146f299c321b1d7c985682017-01-01T00:00:00Zhttps://www.dovepress.com/improvement-of-impaired-diastolic-left-ventricular-function-after-diet-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Sevda Karimian,1 Juergen Stein,2 Boris Bauer,3 Claudius Teupe1 1Department of Medicine – Cardiology, 2Department of Medicine – Gastroenterology, 3Department of Radiology, Krankenhaus Sachsenhausen, Teaching Hospital of Goethe University Frankfurt, Frankfurt, Germany Background/objectives: Obesity is independently associated with left ventricular (LV) diastolic dysfunction and altered cardiac morphology. Morbidity and mortality in patients with diastolic dysfunction are similar to values observed in patients with systolic heart failure. We hypothesized that dysfunctional cardiac responses in people with obesity are reversible after weight loss. Thus, we studied the effect of dietary weight reduction on LV diastolic function as well as on cardiac structure using transthoracic echocardiography and tissue Doppler imaging (TDI). Subjects/methods: Thirty-two subjects with obesity underwent a 12-week low-calorie fasting phase of a formula diet. Echocardiographic tissue Doppler indices of diastolic function and measurements of cardiac size were obtained prior to and after the fasting phase. Results: A 12-week diet significantly reduced body mass index from 40.3 ± 6.6 kg/m2 to 33.2 ± 6.1 kg/m2 (p < 0.01). Weight loss was associated with a significant reduction in blood pressure and heart rate. Echocardiography revealed diastolic dysfunction in subjects with obesity, which was improved by dieting. After weight loss, trans-mitral Doppler echocardiography showed a significant reduction in A-wave velocity, from 65.8 ± 19.2 cm/s to 57.0 ± 16.8 cm/s, and an increase in E/A ratio from 1.2 ± 0.4 to 1.4 ± 0.5 (p < 0.01). TDI displayed a significantly lower a′-wave velocity (10.3 ± 2.3 cm/s and 8.9 ± 1.7 cm/s; p < 0.01). Left atrial and LV dimensions were normal and remained unchanged after weight loss. Conclusion: Obesity is associated with diastolic dysfunction. A 12-week low-calorie diet with successful weight loss can reduce blood pressure and heart rate and partially normalize diastolic dysfunction. Keywords: adiposity, echocardiography, tissue Doppler imaging, diastolic function, weight lossKarimian SStein JBauer BTeupe CDove Medical Pressarticleobesityechocardiographytissue Doppler imagingdiastolic functionweight lossSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 19-25 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity echocardiography tissue Doppler imaging diastolic function weight loss Specialties of internal medicine RC581-951
spellingShingle	obesity echocardiography tissue Doppler imaging diastolic function weight loss Specialties of internal medicine RC581-951 Karimian S Stein J Bauer B Teupe C Improvement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity
description	Sevda Karimian,1 Juergen Stein,2 Boris Bauer,3 Claudius Teupe1 1Department of Medicine – Cardiology, 2Department of Medicine – Gastroenterology, 3Department of Radiology, Krankenhaus Sachsenhausen, Teaching Hospital of Goethe University Frankfurt, Frankfurt, Germany Background/objectives: Obesity is independently associated with left ventricular (LV) diastolic dysfunction and altered cardiac morphology. Morbidity and mortality in patients with diastolic dysfunction are similar to values observed in patients with systolic heart failure. We hypothesized that dysfunctional cardiac responses in people with obesity are reversible after weight loss. Thus, we studied the effect of dietary weight reduction on LV diastolic function as well as on cardiac structure using transthoracic echocardiography and tissue Doppler imaging (TDI). Subjects/methods: Thirty-two subjects with obesity underwent a 12-week low-calorie fasting phase of a formula diet. Echocardiographic tissue Doppler indices of diastolic function and measurements of cardiac size were obtained prior to and after the fasting phase. Results: A 12-week diet significantly reduced body mass index from 40.3 ± 6.6 kg/m2 to 33.2 ± 6.1 kg/m2 (p < 0.01). Weight loss was associated with a significant reduction in blood pressure and heart rate. Echocardiography revealed diastolic dysfunction in subjects with obesity, which was improved by dieting. After weight loss, trans-mitral Doppler echocardiography showed a significant reduction in A-wave velocity, from 65.8 ± 19.2 cm/s to 57.0 ± 16.8 cm/s, and an increase in E/A ratio from 1.2 ± 0.4 to 1.4 ± 0.5 (p < 0.01). TDI displayed a significantly lower a′-wave velocity (10.3 ± 2.3 cm/s and 8.9 ± 1.7 cm/s; p < 0.01). Left atrial and LV dimensions were normal and remained unchanged after weight loss. Conclusion: Obesity is associated with diastolic dysfunction. A 12-week low-calorie diet with successful weight loss can reduce blood pressure and heart rate and partially normalize diastolic dysfunction. Keywords: adiposity, echocardiography, tissue Doppler imaging, diastolic function, weight loss
format	article
author	Karimian S Stein J Bauer B Teupe C
author_facet	Karimian S Stein J Bauer B Teupe C
author_sort	Karimian S
title	Improvement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity
title_short	Improvement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity
title_full	Improvement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity
title_fullStr	Improvement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity
title_full_unstemmed	Improvement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity
title_sort	improvement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/6851684d63a146f299c321b1d7c98568
work_keys_str_mv	AT karimians improvementofimpaireddiastolicleftventricularfunctionafterdietinducedweightreductioninsevereobesity AT steinj improvementofimpaireddiastolicleftventricularfunctionafterdietinducedweightreductioninsevereobesity AT bauerb improvementofimpaireddiastolicleftventricularfunctionafterdietinducedweightreductioninsevereobesity AT teupec improvementofimpaireddiastolicleftventricularfunctionafterdietinducedweightreductioninsevereobesity
_version_	1718400475452145664

Improvement of impaired diastolic left ventricular function after diet-induced weight reduction in severe obesity

Ejemplares similares