Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells

The diversity of antigen receptor specificities is largely generated by random recombination of its segments. Here the authors show, by genetic comparison of monozygotic twin lymphocyte subsets, that individual genetic and epigenetic biases also contribute to the shape of the B and T cell repertoire...

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Autores principales:	Florian Rubelt, Christopher R. Bolen, Helen M. McGuire, Jason A. Vander Heiden, Daniel Gadala-Maria, Mikhail Levin, Ghia M. Euskirchen, Murad R. Mamedov, Gary E. Swan, Cornelia L. Dekker, Lindsay G. Cowell, Steven H. Kleinstein, Mark M. Davis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6853a3a371674e3b9bf79b0d8c6ab451
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spelling	oai:doaj.org-article:6853a3a371674e3b9bf79b0d8c6ab4512021-12-02T17:32:37ZIndividual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells10.1038/ncomms111122041-1723https://doaj.org/article/6853a3a371674e3b9bf79b0d8c6ab4512016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11112https://doaj.org/toc/2041-1723The diversity of antigen receptor specificities is largely generated by random recombination of its segments. Here the authors show, by genetic comparison of monozygotic twin lymphocyte subsets, that individual genetic and epigenetic biases also contribute to the shape of the B and T cell repertoires.Florian RubeltChristopher R. BolenHelen M. McGuireJason A. Vander HeidenDaniel Gadala-MariaMikhail LevinGhia M. EuskirchenMurad R. MamedovGary E. SwanCornelia L. DekkerLindsay G. CowellSteven H. KleinsteinMark M. DavisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florian Rubelt Christopher R. Bolen Helen M. McGuire Jason A. Vander Heiden Daniel Gadala-Maria Mikhail Levin Ghia M. Euskirchen Murad R. Mamedov Gary E. Swan Cornelia L. Dekker Lindsay G. Cowell Steven H. Kleinstein Mark M. Davis Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
description	The diversity of antigen receptor specificities is largely generated by random recombination of its segments. Here the authors show, by genetic comparison of monozygotic twin lymphocyte subsets, that individual genetic and epigenetic biases also contribute to the shape of the B and T cell repertoires.
format	article
author	Florian Rubelt Christopher R. Bolen Helen M. McGuire Jason A. Vander Heiden Daniel Gadala-Maria Mikhail Levin Ghia M. Euskirchen Murad R. Mamedov Gary E. Swan Cornelia L. Dekker Lindsay G. Cowell Steven H. Kleinstein Mark M. Davis
author_facet	Florian Rubelt Christopher R. Bolen Helen M. McGuire Jason A. Vander Heiden Daniel Gadala-Maria Mikhail Levin Ghia M. Euskirchen Murad R. Mamedov Gary E. Swan Cornelia L. Dekker Lindsay G. Cowell Steven H. Kleinstein Mark M. Davis
author_sort	Florian Rubelt
title	Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
title_short	Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
title_full	Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
title_fullStr	Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
title_full_unstemmed	Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
title_sort	individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6853a3a371674e3b9bf79b0d8c6ab451
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Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells

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