Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells

The diversity of antigen receptor specificities is largely generated by random recombination of its segments. Here the authors show, by genetic comparison of monozygotic twin lymphocyte subsets, that individual genetic and epigenetic biases also contribute to the shape of the B and T cell repertoire...

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Bibliographic Details
Main Authors: Florian Rubelt, Christopher R. Bolen, Helen M. McGuire, Jason A. Vander Heiden, Daniel Gadala-Maria, Mikhail Levin, Ghia M. Euskirchen, Murad R. Mamedov, Gary E. Swan, Cornelia L. Dekker, Lindsay G. Cowell, Steven H. Kleinstein, Mark M. Davis
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Q
Online Access:https://doaj.org/article/6853a3a371674e3b9bf79b0d8c6ab451
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