Is It Time To Kill the Survival Curve? A Case for Disease Progression Factors in Microbial Pathogenesis and Host Defense Research

The molecular mechanisms of microbial virulence and host defense are most often studied using animal models and Koch’s molecular postulates. A common rationale for these types of experiments is to identify therapeutic targets based on the assumption that microbial or host factors that confer extrem...

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Autores principales:	Robert A. Cramer, Caitlin H. Kowalski
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/68541e4a675a48dbacbc9ad71ecc63eb
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spelling	oai:doaj.org-article:68541e4a675a48dbacbc9ad71ecc63eb2021-11-03T18:15:37ZIs It Time To Kill the Survival Curve? A Case for Disease Progression Factors in Microbial Pathogenesis and Host Defense Research2161-21292150-751110.1128/mBio.03483-20https://doaj.org/article/68541e4a675a48dbacbc9ad71ecc63eb2021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03483-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 The molecular mechanisms of microbial virulence and host defense are most often studied using animal models and Koch’s molecular postulates. A common rationale for these types of experiments is to identify therapeutic targets based on the assumption that microbial or host factors that confer extreme animal model survival phenotypes represent critical virulence and host defense factors.Robert A. CramerCaitlin H. KowalskiAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Robert A. Cramer Caitlin H. Kowalski Is It Time To Kill the Survival Curve? A Case for Disease Progression Factors in Microbial Pathogenesis and Host Defense Research
description	The molecular mechanisms of microbial virulence and host defense are most often studied using animal models and Koch’s molecular postulates. A common rationale for these types of experiments is to identify therapeutic targets based on the assumption that microbial or host factors that confer extreme animal model survival phenotypes represent critical virulence and host defense factors.
format	article
author	Robert A. Cramer Caitlin H. Kowalski
author_facet	Robert A. Cramer Caitlin H. Kowalski
author_sort	Robert A. Cramer
title	Is It Time To Kill the Survival Curve? A Case for Disease Progression Factors in Microbial Pathogenesis and Host Defense Research
title_short	Is It Time To Kill the Survival Curve? A Case for Disease Progression Factors in Microbial Pathogenesis and Host Defense Research
title_full	Is It Time To Kill the Survival Curve? A Case for Disease Progression Factors in Microbial Pathogenesis and Host Defense Research
title_fullStr	Is It Time To Kill the Survival Curve? A Case for Disease Progression Factors in Microbial Pathogenesis and Host Defense Research
title_full_unstemmed	Is It Time To Kill the Survival Curve? A Case for Disease Progression Factors in Microbial Pathogenesis and Host Defense Research
title_sort	is it time to kill the survival curve? a case for disease progression factors in microbial pathogenesis and host defense research
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/68541e4a675a48dbacbc9ad71ecc63eb
work_keys_str_mv	AT robertacramer isittimetokillthesurvivalcurveacasefordiseaseprogressionfactorsinmicrobialpathogenesisandhostdefenseresearch AT caitlinhkowalski isittimetokillthesurvivalcurveacasefordiseaseprogressionfactorsinmicrobialpathogenesisandhostdefenseresearch
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Is It Time To Kill the Survival Curve? A Case for Disease Progression Factors in Microbial Pathogenesis and Host Defense Research

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