Adaptive temperature compensation in circadian oscillations.

A temperature independent period and temperature entrainment are two defining features of circadian oscillators. A default model of distributed temperature compensation satisfies these basic facts yet is not easily reconciled with other properties of circadian clocks, such as many mutants with alter...

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Autores principales:	Paul François, Nicolas Despierre, Eric D Siggia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/685794544e134a759cfad4bcaea96249
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spelling	oai:doaj.org-article:685794544e134a759cfad4bcaea962492021-11-18T05:51:10ZAdaptive temperature compensation in circadian oscillations.1553-734X1553-735810.1371/journal.pcbi.1002585https://doaj.org/article/685794544e134a759cfad4bcaea962492012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22807663/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358A temperature independent period and temperature entrainment are two defining features of circadian oscillators. A default model of distributed temperature compensation satisfies these basic facts yet is not easily reconciled with other properties of circadian clocks, such as many mutants with altered but temperature compensated periods. The default model also suggests that the shape of the circadian limit cycle and the associated phase response curves (PRC) will vary since the average concentrations of clock proteins change with temperature. We propose an alternative class of models where the twin properties of a fixed period and entrainment are structural and arise from an underlying adaptive system that buffers temperature changes. These models are distinguished by a PRC whose shape is temperature independent and orbits whose extrema are temperature independent. They are readily evolved by local, hill climbing, optimization of gene networks for a common quality measure of biological clocks, phase anticipation. Interestingly a standard realization of the Goodwin model for temperature compensation displays properties of adaptive rather than distributed temperature compensation.Paul FrançoisNicolas DespierreEric D SiggiaPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 7, p e1002585 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Paul François Nicolas Despierre Eric D Siggia Adaptive temperature compensation in circadian oscillations.
description	A temperature independent period and temperature entrainment are two defining features of circadian oscillators. A default model of distributed temperature compensation satisfies these basic facts yet is not easily reconciled with other properties of circadian clocks, such as many mutants with altered but temperature compensated periods. The default model also suggests that the shape of the circadian limit cycle and the associated phase response curves (PRC) will vary since the average concentrations of clock proteins change with temperature. We propose an alternative class of models where the twin properties of a fixed period and entrainment are structural and arise from an underlying adaptive system that buffers temperature changes. These models are distinguished by a PRC whose shape is temperature independent and orbits whose extrema are temperature independent. They are readily evolved by local, hill climbing, optimization of gene networks for a common quality measure of biological clocks, phase anticipation. Interestingly a standard realization of the Goodwin model for temperature compensation displays properties of adaptive rather than distributed temperature compensation.
format	article
author	Paul François Nicolas Despierre Eric D Siggia
author_facet	Paul François Nicolas Despierre Eric D Siggia
author_sort	Paul François
title	Adaptive temperature compensation in circadian oscillations.
title_short	Adaptive temperature compensation in circadian oscillations.
title_full	Adaptive temperature compensation in circadian oscillations.
title_fullStr	Adaptive temperature compensation in circadian oscillations.
title_full_unstemmed	Adaptive temperature compensation in circadian oscillations.
title_sort	adaptive temperature compensation in circadian oscillations.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/685794544e134a759cfad4bcaea96249
work_keys_str_mv	AT paulfrancois adaptivetemperaturecompensationincircadianoscillations AT nicolasdespierre adaptivetemperaturecompensationincircadianoscillations AT ericdsiggia adaptivetemperaturecompensationincircadianoscillations
_version_	1718424731445624832

Adaptive temperature compensation in circadian oscillations.

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