Direct observation of dynamic protein interactions involving human microtubules using solid-state NMR spectroscopy

Direct observation of dynamic protein interactions involving human microtubules using solid-state NMR spectroscopy

Microtubule (MT) organization is regulated by many microtubule-associated proteins (MAPs) that contain intrinsically disordered regions. Here authors produce [13C, 15N] labeled, functional microtubules from human cells for solid-state NMR which allows studying MAP-MT interactions.

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Autores principales: Yanzhang Luo, ShengQi Xiang, Peter Jan Hooikaas, Laura van Bezouwen, A. S. Jijumon, Carsten Janke, Friedrich Förster, Anna Akhmanova, Marc Baldus
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/6857f9ffb0814bc9a9cc46cdf3ff87e4
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