Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia

Background: Increasing evidence from modern neuroimaging has confirmed that cervical dystonia (CD) is caused by network abnormalities. Specific brain networks are known to be crucial in patients suffering from CD. However, changes in network homogeneity (NH) in CD patients have not been characterize...

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Autores principales:	Shubao Wei, Xiuqiong Chen, Yousheng Xiao, Wenyan Jiang, Qiong Yin, Chunhui Lu, Lu Yang, Jing Wei, Yang Liu, Wenmei Li, Jingqun Tang, Wenbin Guo, Shuguang Luo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cervical dystonia resting-state functional magnetic resonance network homogeneity default mode network superior medial frontal gyrus Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/685e9030646c4b5e995775660fc4f0f4
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spelling	oai:doaj.org-article:685e9030646c4b5e995775660fc4f0f42021-11-05T08:23:18ZAbnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia1664-229510.3389/fneur.2021.729068https://doaj.org/article/685e9030646c4b5e995775660fc4f0f42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.729068/fullhttps://doaj.org/toc/1664-2295Background: Increasing evidence from modern neuroimaging has confirmed that cervical dystonia (CD) is caused by network abnormalities. Specific brain networks are known to be crucial in patients suffering from CD. However, changes in network homogeneity (NH) in CD patients have not been characterized. Therefore, the purpose of this study was to investigate the NH of patients with CD.Methods: An automated NH method was used to analyze resting-state functional magnetic resonance (fMRI) data from 19 patients with CD and 21 gender- and age-matched healthy controls (HC). Correlation analysis were conducted between NH, illness duration and symptom severity measured by the Tsui scale.Results: Compared with the HC group, CD patients showed a lower NH in the right superior medial frontal gyrus. No significant correlations were found between abnormal NH values and illness duration or symptom severity.Conclusion: Our findings suggest the existence of abnormal NH in the default mode network (DMN) of CD patients, and thereby highlight the importance of the DMN in the pathophysiology of CD.Shubao WeiXiuqiong ChenYousheng XiaoWenyan JiangQiong YinChunhui LuLu YangJing WeiYang LiuWenmei LiJingqun TangWenbin GuoShuguang LuoFrontiers Media S.A.articlecervical dystoniaresting-state functional magnetic resonancenetwork homogeneitydefault mode networksuperior medial frontal gyrusNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical dystonia resting-state functional magnetic resonance network homogeneity default mode network superior medial frontal gyrus Neurology. Diseases of the nervous system RC346-429
spellingShingle	cervical dystonia resting-state functional magnetic resonance network homogeneity default mode network superior medial frontal gyrus Neurology. Diseases of the nervous system RC346-429 Shubao Wei Xiuqiong Chen Yousheng Xiao Wenyan Jiang Qiong Yin Chunhui Lu Lu Yang Jing Wei Yang Liu Wenmei Li Jingqun Tang Wenbin Guo Shuguang Luo Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia
description	Background: Increasing evidence from modern neuroimaging has confirmed that cervical dystonia (CD) is caused by network abnormalities. Specific brain networks are known to be crucial in patients suffering from CD. However, changes in network homogeneity (NH) in CD patients have not been characterized. Therefore, the purpose of this study was to investigate the NH of patients with CD.Methods: An automated NH method was used to analyze resting-state functional magnetic resonance (fMRI) data from 19 patients with CD and 21 gender- and age-matched healthy controls (HC). Correlation analysis were conducted between NH, illness duration and symptom severity measured by the Tsui scale.Results: Compared with the HC group, CD patients showed a lower NH in the right superior medial frontal gyrus. No significant correlations were found between abnormal NH values and illness duration or symptom severity.Conclusion: Our findings suggest the existence of abnormal NH in the default mode network (DMN) of CD patients, and thereby highlight the importance of the DMN in the pathophysiology of CD.
format	article
author	Shubao Wei Xiuqiong Chen Yousheng Xiao Wenyan Jiang Qiong Yin Chunhui Lu Lu Yang Jing Wei Yang Liu Wenmei Li Jingqun Tang Wenbin Guo Shuguang Luo
author_facet	Shubao Wei Xiuqiong Chen Yousheng Xiao Wenyan Jiang Qiong Yin Chunhui Lu Lu Yang Jing Wei Yang Liu Wenmei Li Jingqun Tang Wenbin Guo Shuguang Luo
author_sort	Shubao Wei
title	Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia
title_short	Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia
title_full	Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia
title_fullStr	Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia
title_full_unstemmed	Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia
title_sort	abnormal network homogeneity in the right superior medial frontal gyrus in cervical dystonia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/685e9030646c4b5e995775660fc4f0f4
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Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia

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