Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer

Gastric cancer is the fifth most common cancer type in the world. The incidence and mortality of gastric cancer in China ranks second among malignant tumors in the country. At present, the main treatment method of gastric cancer is still surgical resection combined with chemotherapy. However, chemot...

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Autores principales:	Lijun Tang, Jinhui Chen, Jin Yin, Mingli Fang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/68604c4a3c38442ba310ab291b5f9a7b
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spelling	oai:doaj.org-article:68604c4a3c38442ba310ab291b5f9a7b2021-11-22T01:09:45ZScreening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer2090-907110.1155/2021/6056636https://doaj.org/article/68604c4a3c38442ba310ab291b5f9a7b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6056636https://doaj.org/toc/2090-9071Gastric cancer is the fifth most common cancer type in the world. The incidence and mortality of gastric cancer in China ranks second among malignant tumors in the country. At present, the main treatment method of gastric cancer is still surgical resection combined with chemotherapy. However, chemotherapy drugs will cause serious toxic and side effects on other normal tissues and cells. At the same time, chemotherapy drugs can make patients develop drug resistance and seriously affect the curative effect. By contrast, Chinese medicine has more advantages in the treatment of cancer. Dangshen (Radix Codonopsis), a traditional Chinese medicine, has been proved to be effective for the clinical treatment of gastric cancer. However, due to the complex components of Dangshen, the main active components and pharmacological mechanism for its treatment of gastric cancer are still unclear. In this study, the main active components and pharmacological mechanism of Radix Codonopsis in the treatment of gastric cancer were preliminarily explored based on network pharmacology and molecular docking. We obtained bioactive compounds and targets from Radix Codonopsis from the Chinese Medicine System Pharmacology Database (TCMSP) and constructed the active ingredient-target network of Codonopsis pilosula. We then obtained targets related to gastric cancer from the disease database. The common targets of Radix Codonopsis and gastric cancer were the key target of Radix Codonopsis for the treatment of gastric cancer. Then, we used Metascapedatabase to conduct functional enrichment analysis on the key targets of Radix Codonopsis for the treatment of gastric cancer to clarify the mechanism of Radix Codonopsis for the treatment of gastric cancer. We constructed a network to screen the main bioactive compounds and therapeutic targets, assessed the prognostic value of the main target genes by survival analysis, and finally assessed the binding affinity of the main target genes and main bioactive compounds of Radix Codonopsis for the treatment of gastric cancer by molecular docking. The results showed that the main active compounds of Codonopsis pilosula in treating gastric cancer were luteolin and cryptotanshinone, which played a role in the treatment of gastric cancer through the multitarget and multipathway mechanism.Lijun TangJinhui ChenJin YinMingli FangHindawi LimitedarticleChemistryQD1-999ENJournal of Chemistry, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Lijun Tang Jinhui Chen Jin Yin Mingli Fang Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer
description	Gastric cancer is the fifth most common cancer type in the world. The incidence and mortality of gastric cancer in China ranks second among malignant tumors in the country. At present, the main treatment method of gastric cancer is still surgical resection combined with chemotherapy. However, chemotherapy drugs will cause serious toxic and side effects on other normal tissues and cells. At the same time, chemotherapy drugs can make patients develop drug resistance and seriously affect the curative effect. By contrast, Chinese medicine has more advantages in the treatment of cancer. Dangshen (Radix Codonopsis), a traditional Chinese medicine, has been proved to be effective for the clinical treatment of gastric cancer. However, due to the complex components of Dangshen, the main active components and pharmacological mechanism for its treatment of gastric cancer are still unclear. In this study, the main active components and pharmacological mechanism of Radix Codonopsis in the treatment of gastric cancer were preliminarily explored based on network pharmacology and molecular docking. We obtained bioactive compounds and targets from Radix Codonopsis from the Chinese Medicine System Pharmacology Database (TCMSP) and constructed the active ingredient-target network of Codonopsis pilosula. We then obtained targets related to gastric cancer from the disease database. The common targets of Radix Codonopsis and gastric cancer were the key target of Radix Codonopsis for the treatment of gastric cancer. Then, we used Metascapedatabase to conduct functional enrichment analysis on the key targets of Radix Codonopsis for the treatment of gastric cancer to clarify the mechanism of Radix Codonopsis for the treatment of gastric cancer. We constructed a network to screen the main bioactive compounds and therapeutic targets, assessed the prognostic value of the main target genes by survival analysis, and finally assessed the binding affinity of the main target genes and main bioactive compounds of Radix Codonopsis for the treatment of gastric cancer by molecular docking. The results showed that the main active compounds of Codonopsis pilosula in treating gastric cancer were luteolin and cryptotanshinone, which played a role in the treatment of gastric cancer through the multitarget and multipathway mechanism.
format	article
author	Lijun Tang Jinhui Chen Jin Yin Mingli Fang
author_facet	Lijun Tang Jinhui Chen Jin Yin Mingli Fang
author_sort	Lijun Tang
title	Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer
title_short	Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer
title_full	Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer
title_fullStr	Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer
title_full_unstemmed	Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer
title_sort	screening of active components and key targets of radix codonopsis in the treatment of gastric cancer
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/68604c4a3c38442ba310ab291b5f9a7b
work_keys_str_mv	AT lijuntang screeningofactivecomponentsandkeytargetsofradixcodonopsisinthetreatmentofgastriccancer AT jinhuichen screeningofactivecomponentsandkeytargetsofradixcodonopsisinthetreatmentofgastriccancer AT jinyin screeningofactivecomponentsandkeytargetsofradixcodonopsisinthetreatmentofgastriccancer AT minglifang screeningofactivecomponentsandkeytargetsofradixcodonopsisinthetreatmentofgastriccancer
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Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer

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