Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC

CRISPR-Cas9 has been utilized, through the fusion of catalytic dead nuclease with chromatin-remodellers, to modify the epigenetic state of specific loci. Here the authors manipulate locus-specific histone acetylation and describe the parameters that need to be considered for its use.

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Detalles Bibliográficos
Autores principales:	Deborah Y. Kwon, Ying-Tao Zhao, Janine M. Lamonica, Zhaolan Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68674fac55494938b72e23f926e02371
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:68674fac55494938b72e23f926e02371
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spelling	oai:doaj.org-article:68674fac55494938b72e23f926e023712021-12-02T15:38:34ZLocus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC10.1038/ncomms153152041-1723https://doaj.org/article/68674fac55494938b72e23f926e023712017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15315https://doaj.org/toc/2041-1723CRISPR-Cas9 has been utilized, through the fusion of catalytic dead nuclease with chromatin-remodellers, to modify the epigenetic state of specific loci. Here the authors manipulate locus-specific histone acetylation and describe the parameters that need to be considered for its use.Deborah Y. KwonYing-Tao ZhaoJanine M. LamonicaZhaolan ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deborah Y. Kwon Ying-Tao Zhao Janine M. Lamonica Zhaolan Zhou Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
description	CRISPR-Cas9 has been utilized, through the fusion of catalytic dead nuclease with chromatin-remodellers, to modify the epigenetic state of specific loci. Here the authors manipulate locus-specific histone acetylation and describe the parameters that need to be considered for its use.
format	article
author	Deborah Y. Kwon Ying-Tao Zhao Janine M. Lamonica Zhaolan Zhou
author_facet	Deborah Y. Kwon Ying-Tao Zhao Janine M. Lamonica Zhaolan Zhou
author_sort	Deborah Y. Kwon
title	Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
title_short	Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
title_full	Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
title_fullStr	Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
title_full_unstemmed	Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
title_sort	locus-specific histone deacetylation using a synthetic crispr-cas9-based hdac
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/68674fac55494938b72e23f926e02371
work_keys_str_mv	AT deborahykwon locusspecifichistonedeacetylationusingasyntheticcrisprcas9basedhdac AT yingtaozhao locusspecifichistonedeacetylationusingasyntheticcrisprcas9basedhdac AT janinemlamonica locusspecifichistonedeacetylationusingasyntheticcrisprcas9basedhdac AT zhaolanzhou locusspecifichistonedeacetylationusingasyntheticcrisprcas9basedhdac
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Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC

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