miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)

Programmed cell death 6 (PDCD6) is a well-known apoptosis regulator that is involved in the immunity of mammals. However, the effects of miRNA-mediated regulation of PDCD6 expression on apoptosis and virus infection in organisms, especially in marine invertebrates, have not been extensively explored...

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Autores principales:	Yi Gong, Tongtong Kong, Xin Ren, Shanmeng Lin, Shengkang Li
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	mir-9875 pdcd6 apoptosis wssv scylla paramamosain Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/6869609e446b47329d610f04e9237a81
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spelling	oai:doaj.org-article:6869609e446b47329d610f04e9237a812021-11-17T14:21:58ZmiR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)2150-55942150-560810.1080/21505594.2020.1787078https://doaj.org/article/6869609e446b47329d610f04e9237a812020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1787078https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Programmed cell death 6 (PDCD6) is a well-known apoptosis regulator that is involved in the immunity of mammals. However, the effects of miRNA-mediated regulation of PDCD6 expression on apoptosis and virus infection in organisms, especially in marine invertebrates, have not been extensively explored. In this study, PDCD6 of mud crab (Scylla paramamosain) (Sp-PDCD6) was characterized. The results showed that Sp-PDCD6 contains five EF-hands domains and could suppress virus infection via apoptosis promotion. It also presented that Sp-PDCD6 was directly targeted by miR-9875 in vitro and in vivo, miR-9875 served as a positive regulator during the virus invasion. The findings indicated that the miR-9875-PDCD6 pathway possessed fundamental effects on the immune response to virus infection in mud crab. Therefore, our research provided a novel insight into the roles of both miR-9875 and PDCD6 in the regulation of apoptosis and virus defense in mud crab.Yi GongTongtong KongXin RenShanmeng LinShengkang LiTaylor & Francis Grouparticlemir-9875pdcd6apoptosiswssvscylla paramamosainInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 848-861 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	mir-9875 pdcd6 apoptosis wssv scylla paramamosain Infectious and parasitic diseases RC109-216
spellingShingle	mir-9875 pdcd6 apoptosis wssv scylla paramamosain Infectious and parasitic diseases RC109-216 Yi Gong Tongtong Kong Xin Ren Shanmeng Lin Shengkang Li miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)
description	Programmed cell death 6 (PDCD6) is a well-known apoptosis regulator that is involved in the immunity of mammals. However, the effects of miRNA-mediated regulation of PDCD6 expression on apoptosis and virus infection in organisms, especially in marine invertebrates, have not been extensively explored. In this study, PDCD6 of mud crab (Scylla paramamosain) (Sp-PDCD6) was characterized. The results showed that Sp-PDCD6 contains five EF-hands domains and could suppress virus infection via apoptosis promotion. It also presented that Sp-PDCD6 was directly targeted by miR-9875 in vitro and in vivo, miR-9875 served as a positive regulator during the virus invasion. The findings indicated that the miR-9875-PDCD6 pathway possessed fundamental effects on the immune response to virus infection in mud crab. Therefore, our research provided a novel insight into the roles of both miR-9875 and PDCD6 in the regulation of apoptosis and virus defense in mud crab.
format	article
author	Yi Gong Tongtong Kong Xin Ren Shanmeng Lin Shengkang Li
author_facet	Yi Gong Tongtong Kong Xin Ren Shanmeng Lin Shengkang Li
author_sort	Yi Gong
title	miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)
title_short	miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)
title_full	miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)
title_fullStr	miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)
title_full_unstemmed	miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)
title_sort	mir-9875 functions in antiviral immunity by targeting pdcd6 in mud crab (scylla paramamosain)
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/6869609e446b47329d610f04e9237a81
work_keys_str_mv	AT yigong mir9875functionsinantiviralimmunitybytargetingpdcd6inmudcrabscyllaparamamosain AT tongtongkong mir9875functionsinantiviralimmunitybytargetingpdcd6inmudcrabscyllaparamamosain AT xinren mir9875functionsinantiviralimmunitybytargetingpdcd6inmudcrabscyllaparamamosain AT shanmenglin mir9875functionsinantiviralimmunitybytargetingpdcd6inmudcrabscyllaparamamosain AT shengkangli mir9875functionsinantiviralimmunitybytargetingpdcd6inmudcrabscyllaparamamosain
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miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (Scylla paramamosain)

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