Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

Cdc48/p97 is a key component of the ubiquitin-proteasome system, acting as a ubiquitin-directed segregase to regulate multiple cellular functions. Here the authors identify UBXN-3/FAF1 as a crucial regulator of chromatin-associated protein degradation that recruits Cdc48/p97 to DNA replication forks...

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Autores principales:	André Franz, Paul A. Pirson, Domenic Pilger, Swagata Halder, Divya Achuthankutty, Hamid Kashkar, Kristijan Ramadan, Thorsten Hoppe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/686b5c06127b4ab8a306f8fad9fed186
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spelling	oai:doaj.org-article:686b5c06127b4ab8a306f8fad9fed1862021-12-02T14:39:52ZChromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression10.1038/ncomms106122041-1723https://doaj.org/article/686b5c06127b4ab8a306f8fad9fed1862016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10612https://doaj.org/toc/2041-1723Cdc48/p97 is a key component of the ubiquitin-proteasome system, acting as a ubiquitin-directed segregase to regulate multiple cellular functions. Here the authors identify UBXN-3/FAF1 as a crucial regulator of chromatin-associated protein degradation that recruits Cdc48/p97 to DNA replication forks.André FranzPaul A. PirsonDomenic PilgerSwagata HalderDivya AchuthankuttyHamid KashkarKristijan RamadanThorsten HoppeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q André Franz Paul A. Pirson Domenic Pilger Swagata Halder Divya Achuthankutty Hamid Kashkar Kristijan Ramadan Thorsten Hoppe Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
description	Cdc48/p97 is a key component of the ubiquitin-proteasome system, acting as a ubiquitin-directed segregase to regulate multiple cellular functions. Here the authors identify UBXN-3/FAF1 as a crucial regulator of chromatin-associated protein degradation that recruits Cdc48/p97 to DNA replication forks.
format	article
author	André Franz Paul A. Pirson Domenic Pilger Swagata Halder Divya Achuthankutty Hamid Kashkar Kristijan Ramadan Thorsten Hoppe
author_facet	André Franz Paul A. Pirson Domenic Pilger Swagata Halder Divya Achuthankutty Hamid Kashkar Kristijan Ramadan Thorsten Hoppe
author_sort	André Franz
title	Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
title_short	Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
title_full	Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
title_fullStr	Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
title_full_unstemmed	Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression
title_sort	chromatin-associated degradation is defined by ubxn-3/faf1 to safeguard dna replication fork progression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/686b5c06127b4ab8a306f8fad9fed186
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Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

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