Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

Cdc48/p97 is a key component of the ubiquitin-proteasome system, acting as a ubiquitin-directed segregase to regulate multiple cellular functions. Here the authors identify UBXN-3/FAF1 as a crucial regulator of chromatin-associated protein degradation that recruits Cdc48/p97 to DNA replication forks...

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Autores principales: André Franz, Paul A. Pirson, Domenic Pilger, Swagata Halder, Divya Achuthankutty, Hamid Kashkar, Kristijan Ramadan, Thorsten Hoppe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/686b5c06127b4ab8a306f8fad9fed186
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