Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma

Abstract Background The present study compared the effectiveness and toxicity of two treatment modalities, namely radiotherapy combined with nimotuzumab (N) and chemoradiotherapy (CRT) in patients with locally recurrent nasopharyngeal carcinoma (LR-NPC). Methods Patients with LR-NPC who were treated...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jing-Feng Zong, Qian-Dong Liang, Qiong-Jiao Lu, Yu-Hong Liu, Han-Chuan Xu, Bi-Juan Chen, Qiao-Juan Guo, Yun Xu, Cai-Rong Hu, Jian-Ji Pan, Shao-Jun Lin
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Locally recurrent nasopharyngeal carcinoma Radiotherapy Nimotuzumab Chemoradiotherapy Toxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/686f13e2504447ebbf76abc74ff8cea8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:686f13e2504447ebbf76abc74ff8cea8
record_format	dspace
spelling	oai:doaj.org-article:686f13e2504447ebbf76abc74ff8cea82021-11-28T12:27:26ZComparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma10.1186/s12885-021-08995-y1471-2407https://doaj.org/article/686f13e2504447ebbf76abc74ff8cea82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08995-yhttps://doaj.org/toc/1471-2407Abstract Background The present study compared the effectiveness and toxicity of two treatment modalities, namely radiotherapy combined with nimotuzumab (N) and chemoradiotherapy (CRT) in patients with locally recurrent nasopharyngeal carcinoma (LR-NPC). Methods Patients with LR-NPC who were treated with radiotherapy were retrospectively enrolled from January 2015 to December 2018. The treatment included radiotherapy combined with N or platinum-based induction chemotherapy and/or concurrent chemotherapy. The comparison of survival and toxicity between the two treatment modalities was evaluated using the log-rank and chi-squared tests. Overall survival (OS) was the primary endpoint. Results A total of 87 patients were included, of whom 32 and 55 were divided into the N group and the CRT group, respectively. No significant differences were noted in the survival rate between the N and the CRT groups (4-year OS rates, 37.1% vs. 40.7%, respectively; P = 0.735). Mild to moderate acute complications were common during the radiation period and mainly included mucositis and xerostomia. The majority of the acute toxic reactions were tolerated well. A total of 48 patients (55.2%) demonstrated late radiation injuries of grade ≥ 3, including 12 patients (37.5%) in the N group and 36 patients (66.5%) in the CRT group. The CRT group exhibited significantly higher incidence of severe late radiation injuries compared with that of the N group (P = 0.011). Conclusion Radiotherapy combined with N did not appear to enhance treatment efficacy compared with CRT in patients with LR-NPC. However, radiotherapy combined with N may be superior to CRT due to its lower incidence of acute and late toxicities. Further studies are required to confirm the current findings.Jing-Feng ZongQian-Dong LiangQiong-Jiao LuYu-Hong LiuHan-Chuan XuBi-Juan ChenQiao-Juan GuoYun XuCai-Rong HuJian-Ji PanShao-Jun LinBMCarticleLocally recurrent nasopharyngeal carcinomaRadiotherapyNimotuzumabChemoradiotherapyToxicityNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Locally recurrent nasopharyngeal carcinoma Radiotherapy Nimotuzumab Chemoradiotherapy Toxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Locally recurrent nasopharyngeal carcinoma Radiotherapy Nimotuzumab Chemoradiotherapy Toxicity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jing-Feng Zong Qian-Dong Liang Qiong-Jiao Lu Yu-Hong Liu Han-Chuan Xu Bi-Juan Chen Qiao-Juan Guo Yun Xu Cai-Rong Hu Jian-Ji Pan Shao-Jun Lin Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma
description	Abstract Background The present study compared the effectiveness and toxicity of two treatment modalities, namely radiotherapy combined with nimotuzumab (N) and chemoradiotherapy (CRT) in patients with locally recurrent nasopharyngeal carcinoma (LR-NPC). Methods Patients with LR-NPC who were treated with radiotherapy were retrospectively enrolled from January 2015 to December 2018. The treatment included radiotherapy combined with N or platinum-based induction chemotherapy and/or concurrent chemotherapy. The comparison of survival and toxicity between the two treatment modalities was evaluated using the log-rank and chi-squared tests. Overall survival (OS) was the primary endpoint. Results A total of 87 patients were included, of whom 32 and 55 were divided into the N group and the CRT group, respectively. No significant differences were noted in the survival rate between the N and the CRT groups (4-year OS rates, 37.1% vs. 40.7%, respectively; P = 0.735). Mild to moderate acute complications were common during the radiation period and mainly included mucositis and xerostomia. The majority of the acute toxic reactions were tolerated well. A total of 48 patients (55.2%) demonstrated late radiation injuries of grade ≥ 3, including 12 patients (37.5%) in the N group and 36 patients (66.5%) in the CRT group. The CRT group exhibited significantly higher incidence of severe late radiation injuries compared with that of the N group (P = 0.011). Conclusion Radiotherapy combined with N did not appear to enhance treatment efficacy compared with CRT in patients with LR-NPC. However, radiotherapy combined with N may be superior to CRT due to its lower incidence of acute and late toxicities. Further studies are required to confirm the current findings.
format	article
author	Jing-Feng Zong Qian-Dong Liang Qiong-Jiao Lu Yu-Hong Liu Han-Chuan Xu Bi-Juan Chen Qiao-Juan Guo Yun Xu Cai-Rong Hu Jian-Ji Pan Shao-Jun Lin
author_facet	Jing-Feng Zong Qian-Dong Liang Qiong-Jiao Lu Yu-Hong Liu Han-Chuan Xu Bi-Juan Chen Qiao-Juan Guo Yun Xu Cai-Rong Hu Jian-Ji Pan Shao-Jun Lin
author_sort	Jing-Feng Zong
title	Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma
title_short	Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma
title_full	Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma
title_fullStr	Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma
title_full_unstemmed	Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma
title_sort	comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/686f13e2504447ebbf76abc74ff8cea8
work_keys_str_mv	AT jingfengzong comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT qiandongliang comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT qiongjiaolu comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT yuhongliu comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT hanchuanxu comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT bijuanchen comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT qiaojuanguo comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT yunxu comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT caironghu comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT jianjipan comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma AT shaojunlin comparisonofradiotherapycombinedwithnimotuzumabvschemoradiotherapyforlocallyrecurrentnasopharyngealcarcinoma
_version_	1718407959701094400

Comparison of radiotherapy combined with nimotuzumab vs. chemoradiotherapy for locally recurrent nasopharyngeal carcinoma

Ejemplares similares