The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson’s disease

Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) alleviates motor symptoms in Parkinson’s disease (PD) but also affects the prefrontal cortex (PFC), potentially leading to cognitive side effects. The present study tested alterations within the rostro-caudal hierarchy of neural pr...

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Autores principales:	F. Konrad Schumacher, Lena V. Schumacher, Florian Amtage, Andreas Horn, Karl Egger, Tobias Piroth, Cornelius Weiller, Björn O. Schelter, Volker A. Coenen, Christoph P. Kaller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/686fb3fdcdb64001a07242580636f946
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spelling	oai:doaj.org-article:686fb3fdcdb64001a07242580636f9462021-12-02T13:51:06ZThe rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson’s disease10.1038/s41598-021-81535-72045-2322https://doaj.org/article/686fb3fdcdb64001a07242580636f9462021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81535-7https://doaj.org/toc/2045-2322Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) alleviates motor symptoms in Parkinson’s disease (PD) but also affects the prefrontal cortex (PFC), potentially leading to cognitive side effects. The present study tested alterations within the rostro-caudal hierarchy of neural processing in the PFC induced by STN-DBS in PD. Granger-causality analyses of fast functional near-infrared spectroscopy (fNIRS) measurements were used to infer directed functional connectivity from intrinsic PFC activity in 24 PD patients treated with STN-DBS. Functional connectivity was assessed ON stimulation, in steady-state OFF stimulation and immediately after the stimulator was switched ON again. Results revealed that STN-DBS significantly enhanced the rostro-caudal hierarchical organization of the PFC in patients who had undergone implantation early in the course of the disease, whereas it attenuated the rostro-caudal hierarchy in late-implanted patients. Most crucially, this systematic network effect of STN-DBS was reproducible in the second ON stimulation measurement. Supplemental analyses demonstrated the significance of prefrontal networks for cognitive functions in patients and matched healthy controls. These findings show that the modulation of prefrontal functional networks by STN-DBS is dependent on the disease duration before DBS implantation and suggest a neurophysiological mechanism underlying the side effects on prefrontally-guided cognitive functions observed under STN-DBS.F. Konrad SchumacherLena V. SchumacherFlorian AmtageAndreas HornKarl EggerTobias PirothCornelius WeillerBjörn O. SchelterVolker A. CoenenChristoph P. KallerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F. Konrad Schumacher Lena V. Schumacher Florian Amtage Andreas Horn Karl Egger Tobias Piroth Cornelius Weiller Björn O. Schelter Volker A. Coenen Christoph P. Kaller The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson’s disease
description	Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) alleviates motor symptoms in Parkinson’s disease (PD) but also affects the prefrontal cortex (PFC), potentially leading to cognitive side effects. The present study tested alterations within the rostro-caudal hierarchy of neural processing in the PFC induced by STN-DBS in PD. Granger-causality analyses of fast functional near-infrared spectroscopy (fNIRS) measurements were used to infer directed functional connectivity from intrinsic PFC activity in 24 PD patients treated with STN-DBS. Functional connectivity was assessed ON stimulation, in steady-state OFF stimulation and immediately after the stimulator was switched ON again. Results revealed that STN-DBS significantly enhanced the rostro-caudal hierarchical organization of the PFC in patients who had undergone implantation early in the course of the disease, whereas it attenuated the rostro-caudal hierarchy in late-implanted patients. Most crucially, this systematic network effect of STN-DBS was reproducible in the second ON stimulation measurement. Supplemental analyses demonstrated the significance of prefrontal networks for cognitive functions in patients and matched healthy controls. These findings show that the modulation of prefrontal functional networks by STN-DBS is dependent on the disease duration before DBS implantation and suggest a neurophysiological mechanism underlying the side effects on prefrontally-guided cognitive functions observed under STN-DBS.
format	article
author	F. Konrad Schumacher Lena V. Schumacher Florian Amtage Andreas Horn Karl Egger Tobias Piroth Cornelius Weiller Björn O. Schelter Volker A. Coenen Christoph P. Kaller
author_facet	F. Konrad Schumacher Lena V. Schumacher Florian Amtage Andreas Horn Karl Egger Tobias Piroth Cornelius Weiller Björn O. Schelter Volker A. Coenen Christoph P. Kaller
author_sort	F. Konrad Schumacher
title	The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson’s disease
title_short	The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson’s disease
title_full	The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson’s disease
title_fullStr	The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson’s disease
title_full_unstemmed	The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson’s disease
title_sort	rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/686fb3fdcdb64001a07242580636f946
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The rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson’s disease

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