Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient

Abstract Aneurysm wall motion has been reported to be associated with rupture. However, its quantification with medical imaging is challenging and should be based on experimental ground-truth to avoid misinterpretation of results. In this work a time-resolved CT angiography (4D-CTA) acquisition prot...

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Autores principales:	Axel E. Vanrossomme, Kamil J. Chodzyński, Omer F. Eker, Karim Zouaoui Boudjeltia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6872c154141e42799857aa2e2d7941bd
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spelling	oai:doaj.org-article:6872c154141e42799857aa2e2d7941bd2021-12-02T15:37:58ZDevelopment of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient10.1038/s41598-021-88420-32045-2322https://doaj.org/article/6872c154141e42799857aa2e2d7941bd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88420-3https://doaj.org/toc/2045-2322Abstract Aneurysm wall motion has been reported to be associated with rupture. However, its quantification with medical imaging is challenging and should be based on experimental ground-truth to avoid misinterpretation of results. In this work a time-resolved CT angiography (4D-CTA) acquisition protocol is proposed to detect the pulsation of intracranial aneurysms with a low radiation dose. To acquire ground-truth data, the accuracy of volume pulsation detection and quantification in a silicone phantom was assessed by applying pressure sinusoidal waves of increasing amplitudes. These experiments were carried out using a test bench that could reproduce pulsatile waveforms similar to those inside the internal carotid arteries of human subjects. 4D-CTA acquisition parameters (mAs, kVp) were then selected to achieve reliable pulsation detection and quantification with the lowest radiation dose achievable. The resulting acquisition protocol was then used to image an anterior communicating artery aneurysm in a human subject. Data reveals that in a simplified in vitro setting 4D-CTA allows for an effective and reproducible method to detect and quantify aneurysm volume pulsation with an inferior limit as low as 3 mm3 and a background noise of 0.5–1 mm3. Aneurysm pulsation can be detected in vivo with a radiation dose approximating 1 mSv.Axel E. VanrossommeKamil J. ChodzyńskiOmer F. EkerKarim Zouaoui BoudjeltiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Axel E. Vanrossomme Kamil J. Chodzyński Omer F. Eker Karim Zouaoui Boudjeltia Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient
description	Abstract Aneurysm wall motion has been reported to be associated with rupture. However, its quantification with medical imaging is challenging and should be based on experimental ground-truth to avoid misinterpretation of results. In this work a time-resolved CT angiography (4D-CTA) acquisition protocol is proposed to detect the pulsation of intracranial aneurysms with a low radiation dose. To acquire ground-truth data, the accuracy of volume pulsation detection and quantification in a silicone phantom was assessed by applying pressure sinusoidal waves of increasing amplitudes. These experiments were carried out using a test bench that could reproduce pulsatile waveforms similar to those inside the internal carotid arteries of human subjects. 4D-CTA acquisition parameters (mAs, kVp) were then selected to achieve reliable pulsation detection and quantification with the lowest radiation dose achievable. The resulting acquisition protocol was then used to image an anterior communicating artery aneurysm in a human subject. Data reveals that in a simplified in vitro setting 4D-CTA allows for an effective and reproducible method to detect and quantify aneurysm volume pulsation with an inferior limit as low as 3 mm3 and a background noise of 0.5–1 mm3. Aneurysm pulsation can be detected in vivo with a radiation dose approximating 1 mSv.
format	article
author	Axel E. Vanrossomme Kamil J. Chodzyński Omer F. Eker Karim Zouaoui Boudjeltia
author_facet	Axel E. Vanrossomme Kamil J. Chodzyński Omer F. Eker Karim Zouaoui Boudjeltia
author_sort	Axel E. Vanrossomme
title	Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient
title_short	Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient
title_full	Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient
title_fullStr	Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient
title_full_unstemmed	Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient
title_sort	development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6872c154141e42799857aa2e2d7941bd
work_keys_str_mv	AT axelevanrossomme developmentofexperimentalgroundtruthandquantificationofintracranialaneurysmpulsationinapatient AT kamiljchodzynski developmentofexperimentalgroundtruthandquantificationofintracranialaneurysmpulsationinapatient AT omerfeker developmentofexperimentalgroundtruthandquantificationofintracranialaneurysmpulsationinapatient AT karimzouaouiboudjeltia developmentofexperimentalgroundtruthandquantificationofintracranialaneurysmpulsationinapatient
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Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient

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