Acute myocardial infarction in the postpartum period in the young woman with protein C deficiency

Women of childbearing age without cardiovascular risk factors have low risk of acute myocardial infarction. Pregnancy has been shown to increase the risk of myocardial infarction compared to the risk in non-pregnant women of similar age. Acute myocardial infarction during pregnancy or postpartum per...

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Autores principales:	E. S. Eniseeva, K. V. Protasov, Y. A. Reut, O. M. Senderova, N. V. Shcherbakova, N. V. Petronchak
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	myocardial infarction peripartum period thrombophilia protein c deficiency Science Q
Acceso en línea:	https://doaj.org/article/6875f308ffb34c45ab090cd3c2a4eb65
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spelling	oai:doaj.org-article:6875f308ffb34c45ab090cd3c2a4eb652021-11-23T06:14:40ZAcute myocardial infarction in the postpartum period in the young woman with protein C deficiency2541-94202587-959610.29413/ABS.2018-3.2.22https://doaj.org/article/6875f308ffb34c45ab090cd3c2a4eb652018-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/572https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Women of childbearing age without cardiovascular risk factors have low risk of acute myocardial infarction. Pregnancy has been shown to increase the risk of myocardial infarction compared to the risk in non-pregnant women of similar age. Acute myocardial infarction during pregnancy or postpartum period as a rule develops due to coronary spasm or non-atherogenic thrombosis or spontaneous coronary dissection. Thrombosis is most likely related to hypercoagulable state of pregnancy and postpartum period. It is worth considering the importance of defects of coagulation, such as Leiden factor, protein C, protein S, antithrombin III and mutations of propter genes. There is also the significant role of antiphospholipid antibodies in young women. We present the clinical case of acute ST-elevation myocardial infarction in 34-years old woman without traditional cardiovascular risk factors, which was developed after childbirth due to non-atherogenic left anterior coronary artery thrombosis. Her coagulation profile showed normal results for antithrombin III, protein S, prothrombin gene mutation, factor V Leiden and antiphospholipid antibody syndrome. At the same time the protein C activity decreased to 43 % as well as trombophilia genetic markers MTHFRC677T, MTRR 66A>G, ITGA2:807 C>T and ITGB:1565 T>C genetic polymorphisms were revealed.E. S. EniseevaK. V. ProtasovY. A. ReutO. M. SenderovaN. V. ShcherbakovaN. V. PetronchakScientific Сentre for Family Health and Human Reproduction Problemsarticlemyocardial infarctionperipartum periodthrombophiliaprotein c deficiencyScienceQRUActa Biomedica Scientifica, Vol 3, Iss 2, Pp 121-124 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	myocardial infarction peripartum period thrombophilia protein c deficiency Science Q
spellingShingle	myocardial infarction peripartum period thrombophilia protein c deficiency Science Q E. S. Eniseeva K. V. Protasov Y. A. Reut O. M. Senderova N. V. Shcherbakova N. V. Petronchak Acute myocardial infarction in the postpartum period in the young woman with protein C deficiency
description	Women of childbearing age without cardiovascular risk factors have low risk of acute myocardial infarction. Pregnancy has been shown to increase the risk of myocardial infarction compared to the risk in non-pregnant women of similar age. Acute myocardial infarction during pregnancy or postpartum period as a rule develops due to coronary spasm or non-atherogenic thrombosis or spontaneous coronary dissection. Thrombosis is most likely related to hypercoagulable state of pregnancy and postpartum period. It is worth considering the importance of defects of coagulation, such as Leiden factor, protein C, protein S, antithrombin III and mutations of propter genes. There is also the significant role of antiphospholipid antibodies in young women. We present the clinical case of acute ST-elevation myocardial infarction in 34-years old woman without traditional cardiovascular risk factors, which was developed after childbirth due to non-atherogenic left anterior coronary artery thrombosis. Her coagulation profile showed normal results for antithrombin III, protein S, prothrombin gene mutation, factor V Leiden and antiphospholipid antibody syndrome. At the same time the protein C activity decreased to 43 % as well as trombophilia genetic markers MTHFRC677T, MTRR 66A>G, ITGA2:807 C>T and ITGB:1565 T>C genetic polymorphisms were revealed.
format	article
author	E. S. Eniseeva K. V. Protasov Y. A. Reut O. M. Senderova N. V. Shcherbakova N. V. Petronchak
author_facet	E. S. Eniseeva K. V. Protasov Y. A. Reut O. M. Senderova N. V. Shcherbakova N. V. Petronchak
author_sort	E. S. Eniseeva
title	Acute myocardial infarction in the postpartum period in the young woman with protein C deficiency
title_short	Acute myocardial infarction in the postpartum period in the young woman with protein C deficiency
title_full	Acute myocardial infarction in the postpartum period in the young woman with protein C deficiency
title_fullStr	Acute myocardial infarction in the postpartum period in the young woman with protein C deficiency
title_full_unstemmed	Acute myocardial infarction in the postpartum period in the young woman with protein C deficiency
title_sort	acute myocardial infarction in the postpartum period in the young woman with protein c deficiency
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/6875f308ffb34c45ab090cd3c2a4eb65
work_keys_str_mv	AT eseniseeva acutemyocardialinfarctioninthepostpartumperiodintheyoungwomanwithproteincdeficiency AT kvprotasov acutemyocardialinfarctioninthepostpartumperiodintheyoungwomanwithproteincdeficiency AT yareut acutemyocardialinfarctioninthepostpartumperiodintheyoungwomanwithproteincdeficiency AT omsenderova acutemyocardialinfarctioninthepostpartumperiodintheyoungwomanwithproteincdeficiency AT nvshcherbakova acutemyocardialinfarctioninthepostpartumperiodintheyoungwomanwithproteincdeficiency AT nvpetronchak acutemyocardialinfarctioninthepostpartumperiodintheyoungwomanwithproteincdeficiency
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Acute myocardial infarction in the postpartum period in the young woman with protein C deficiency

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