MODY2 diagnostic issues in adults

Approximately 90% of all cases of diabetes mellitus in adults involve type 2 diabetes, while the prevalence of maturity-onset diabetes of the young (MODY) remains undetermined leading to inappropriate treatment regimens. One of the most common monogenic forms of diabetes is a disease caused by a mut...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Irina V. Kononenko, Anastasiya A. Glibka, Natalya A. Zubkova, Alexander Y. Mayorov, Anatoly N. Tyulpakov, Olga M. Schmidt
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2019
Materias:	diabetes mellitus gck gene maturity-onset diabetes of the young (mody) mody2 gestational diabetes case report Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/687734329d874d88b6d54f1e843edee5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:687734329d874d88b6d54f1e843edee5
record_format	dspace
spelling	oai:doaj.org-article:687734329d874d88b6d54f1e843edee52021-11-14T09:00:22ZMODY2 diagnostic issues in adults2072-03512072-037810.14341/DM10063https://doaj.org/article/687734329d874d88b6d54f1e843edee52019-10-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10063https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Approximately 90% of all cases of diabetes mellitus in adults involve type 2 diabetes, while the prevalence of maturity-onset diabetes of the young (MODY) remains undetermined leading to inappropriate treatment regimens. One of the most common monogenic forms of diabetes is a disease caused by a mutation in the glucokinase gene, MODY2. Knowledge of the clinical features of the disease allows the selection of patients with a high risk of mutation in the glucokinase gene and verification of diagnosis for molecular genetic research. This paper reflects the clinical features of MODY2 and the difficulties of diagnosis in adults. Furthermore, it presents a clinical case of a patient with MODY2 demonstrating all the features of this type of diabetes. A family member with a mutation in the gene allows to predict the nature of carbohydrate metabolism disorders in first degree relatives. A targeted study of only one part of the glucokinase gene in molecular genetic research is sufficient to confirm the diagnosis in relatives.Irina V. KononenkoAnastasiya A. GlibkaNatalya A. ZubkovaAlexander Y. MayorovAnatoly N. TyulpakovOlga M. SchmidtEndocrinology Research Centrearticlediabetes mellitusgck genematurity-onset diabetes of the young (mody)mody2gestational diabetescase reportNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 4, Pp 384-391 (2019)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus gck gene maturity-onset diabetes of the young (mody) mody2 gestational diabetes case report Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus gck gene maturity-onset diabetes of the young (mody) mody2 gestational diabetes case report Nutritional diseases. Deficiency diseases RC620-627 Irina V. Kononenko Anastasiya A. Glibka Natalya A. Zubkova Alexander Y. Mayorov Anatoly N. Tyulpakov Olga M. Schmidt MODY2 diagnostic issues in adults
description	Approximately 90% of all cases of diabetes mellitus in adults involve type 2 diabetes, while the prevalence of maturity-onset diabetes of the young (MODY) remains undetermined leading to inappropriate treatment regimens. One of the most common monogenic forms of diabetes is a disease caused by a mutation in the glucokinase gene, MODY2. Knowledge of the clinical features of the disease allows the selection of patients with a high risk of mutation in the glucokinase gene and verification of diagnosis for molecular genetic research. This paper reflects the clinical features of MODY2 and the difficulties of diagnosis in adults. Furthermore, it presents a clinical case of a patient with MODY2 demonstrating all the features of this type of diabetes. A family member with a mutation in the gene allows to predict the nature of carbohydrate metabolism disorders in first degree relatives. A targeted study of only one part of the glucokinase gene in molecular genetic research is sufficient to confirm the diagnosis in relatives.
format	article
author	Irina V. Kononenko Anastasiya A. Glibka Natalya A. Zubkova Alexander Y. Mayorov Anatoly N. Tyulpakov Olga M. Schmidt
author_facet	Irina V. Kononenko Anastasiya A. Glibka Natalya A. Zubkova Alexander Y. Mayorov Anatoly N. Tyulpakov Olga M. Schmidt
author_sort	Irina V. Kononenko
title	MODY2 diagnostic issues in adults
title_short	MODY2 diagnostic issues in adults
title_full	MODY2 diagnostic issues in adults
title_fullStr	MODY2 diagnostic issues in adults
title_full_unstemmed	MODY2 diagnostic issues in adults
title_sort	mody2 diagnostic issues in adults
publisher	Endocrinology Research Centre
publishDate	2019
url	https://doaj.org/article/687734329d874d88b6d54f1e843edee5
work_keys_str_mv	AT irinavkononenko mody2diagnosticissuesinadults AT anastasiyaaglibka mody2diagnosticissuesinadults AT natalyaazubkova mody2diagnosticissuesinadults AT alexanderymayorov mody2diagnosticissuesinadults AT anatolyntyulpakov mody2diagnosticissuesinadults AT olgamschmidt mody2diagnosticissuesinadults
_version_	1718429534528733184

MODY2 diagnostic issues in adults

Ejemplares similares