Increased S-nitrosylation and proteasomal degradation of caspase-3 during infection contribute to the persistence of adherent invasive Escherichia coli (AIEC) in immune cells.

Adherent invasive Escherichia coli (AIEC) have been implicated as a causative agent of Crohn's disease (CD) due to their isolation from the intestines of CD sufferers and their ability to persist in macrophages inducing granulomas. The rapid intracellular multiplication of AIEC sets it apart fr...

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Autores principales: Karl A Dunne, Amr Allam, Anne McIntosh, Stephanie A Houston, Vuk Cerovic, Carl S Goodyear, Andrew J Roe, Scott A Beatson, Simon W Milling, Daniel Walker, Daniel M Wall
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/68787c7deacb40138493179492bbff82
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