Structural mechanism of laminin recognition by integrin

Structural mechanism of laminin recognition by integrin

Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular detail.

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Autores principales: Takao Arimori, Naoyuki Miyazaki, Emiko Mihara, Mamoru Takizawa, Yukimasa Taniguchi, Carlos Cabañas, Kiyotoshi Sekiguchi, Junichi Takagi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/687deb85420c4b6994fe618c35c25766
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spelling oai:doaj.org-article:687deb85420c4b6994fe618c35c257662021-12-02T18:18:35ZStructural mechanism of laminin recognition by integrin10.1038/s41467-021-24184-82041-1723https://doaj.org/article/687deb85420c4b6994fe618c35c257662021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24184-8https://doaj.org/toc/2041-1723Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular detail.Takao ArimoriNaoyuki MiyazakiEmiko MiharaMamoru TakizawaYukimasa TaniguchiCarlos CabañasKiyotoshi SekiguchiJunichi TakagiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Takao Arimori
Naoyuki Miyazaki
Emiko Mihara
Mamoru Takizawa
Yukimasa Taniguchi
Carlos Cabañas
Kiyotoshi Sekiguchi
Junichi Takagi
Structural mechanism of laminin recognition by integrin
description Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular detail.
format article
author Takao Arimori
Naoyuki Miyazaki
Emiko Mihara
Mamoru Takizawa
Yukimasa Taniguchi
Carlos Cabañas
Kiyotoshi Sekiguchi
Junichi Takagi
author_facet Takao Arimori
Naoyuki Miyazaki
Emiko Mihara
Mamoru Takizawa
Yukimasa Taniguchi
Carlos Cabañas
Kiyotoshi Sekiguchi
Junichi Takagi
author_sort Takao Arimori
title Structural mechanism of laminin recognition by integrin
title_short Structural mechanism of laminin recognition by integrin
title_full Structural mechanism of laminin recognition by integrin
title_fullStr Structural mechanism of laminin recognition by integrin
title_full_unstemmed Structural mechanism of laminin recognition by integrin
title_sort structural mechanism of laminin recognition by integrin
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/687deb85420c4b6994fe618c35c25766
work_keys_str_mv AT takaoarimori structuralmechanismoflamininrecognitionbyintegrin
AT naoyukimiyazaki structuralmechanismoflamininrecognitionbyintegrin
AT emikomihara structuralmechanismoflamininrecognitionbyintegrin
AT mamorutakizawa structuralmechanismoflamininrecognitionbyintegrin
AT yukimasataniguchi structuralmechanismoflamininrecognitionbyintegrin
AT carloscabanas structuralmechanismoflamininrecognitionbyintegrin
AT kiyotoshisekiguchi structuralmechanismoflamininrecognitionbyintegrin
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