Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
Strazza et al. show that phosphoprotein associated with glycosphingolipidenriched microdomains 1 (PAG) is phosphorylated following PD-1 ligation. They find that PAG deletion sensitizes tumors to PD-1 blockade. This study suggests PAG as a critical mediator of PD-1 signaling and a promising target to...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/6881d1a3b36f43a4a4454129bbd534d2 |
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| Sumario: | Strazza et al. show that phosphoprotein associated with glycosphingolipidenriched microdomains 1 (PAG) is phosphorylated following PD-1 ligation. They find that PAG deletion sensitizes tumors to PD-1 blockade. This study suggests PAG as a critical mediator of PD-1 signaling and a promising target to enhance T cell activation in tumors. |
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