Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells

Strazza et al. show that phosphoprotein associated with glycosphingolipidenriched microdomains 1 (PAG) is phosphorylated following PD-1 ligation. They find that PAG deletion sensitizes tumors to PD-1 blockade. This study suggests PAG as a critical mediator of PD-1 signaling and a promising target to...

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Autores principales:	Marianne Strazza, Inbar Azoulay-Alfaguter, Michael Peled, Kieran Adam, Adam Mor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6881d1a3b36f43a4a4454129bbd534d2
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spelling	oai:doaj.org-article:6881d1a3b36f43a4a4454129bbd534d22021-12-02T17:51:05ZTransmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells10.1038/s42003-021-02225-82399-3642https://doaj.org/article/6881d1a3b36f43a4a4454129bbd534d22021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02225-8https://doaj.org/toc/2399-3642Strazza et al. show that phosphoprotein associated with glycosphingolipidenriched microdomains 1 (PAG) is phosphorylated following PD-1 ligation. They find that PAG deletion sensitizes tumors to PD-1 blockade. This study suggests PAG as a critical mediator of PD-1 signaling and a promising target to enhance T cell activation in tumors.Marianne StrazzaInbar Azoulay-AlfaguterMichael PeledKieran AdamAdam MorNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Marianne Strazza Inbar Azoulay-Alfaguter Michael Peled Kieran Adam Adam Mor Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
description	Strazza et al. show that phosphoprotein associated with glycosphingolipidenriched microdomains 1 (PAG) is phosphorylated following PD-1 ligation. They find that PAG deletion sensitizes tumors to PD-1 blockade. This study suggests PAG as a critical mediator of PD-1 signaling and a promising target to enhance T cell activation in tumors.
format	article
author	Marianne Strazza Inbar Azoulay-Alfaguter Michael Peled Kieran Adam Adam Mor
author_facet	Marianne Strazza Inbar Azoulay-Alfaguter Michael Peled Kieran Adam Adam Mor
author_sort	Marianne Strazza
title	Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
title_short	Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
title_full	Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
title_fullStr	Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
title_full_unstemmed	Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells
title_sort	transmembrane adaptor protein pag is a mediator of pd-1 inhibitory signaling in human t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6881d1a3b36f43a4a4454129bbd534d2
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Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells

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