In-silico investigation towards the non-invasive optical detection of blood lactate

Abstract This paper uses Monte Carlo simulations to investigate the interaction of short-wave infrared (SWIR) light with vascular tissue as a step toward the development of a non-invasive optical sensor for measuring blood lactate in humans. The primary focus of this work was to determine the optima...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Subhasri Chatterjee, Karthik Budidha, Meha Qassem, Panicos A. Kyriacou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68874677331d4baca41dc334bc09d189
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:68874677331d4baca41dc334bc09d189
record_format	dspace
spelling	oai:doaj.org-article:68874677331d4baca41dc334bc09d1892021-12-02T16:08:08ZIn-silico investigation towards the non-invasive optical detection of blood lactate10.1038/s41598-021-92803-x2045-2322https://doaj.org/article/68874677331d4baca41dc334bc09d1892021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92803-xhttps://doaj.org/toc/2045-2322Abstract This paper uses Monte Carlo simulations to investigate the interaction of short-wave infrared (SWIR) light with vascular tissue as a step toward the development of a non-invasive optical sensor for measuring blood lactate in humans. The primary focus of this work was to determine the optimal source-detector separation, penetration depth of light at SWIR wavelengths in tissue, and the optimal light power required for reliable detection of lactate. The investigation also focused on determining the non-linear variations in absorbance of lactate at a few select SWIR wavelengths. SWIR photons only penetrated 1.3 mm and did not travel beyond the hypodermal fat layer. The maximum output power was only 2.51% of the input power, demonstrating the need for a highly sensitive detection system. Simulations optimized a source-detector separation of 1 mm at 1684 nm for accurate measurement of lactate in blood.Subhasri ChatterjeeKarthik BudidhaMeha QassemPanicos A. KyriacouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Subhasri Chatterjee Karthik Budidha Meha Qassem Panicos A. Kyriacou In-silico investigation towards the non-invasive optical detection of blood lactate
description	Abstract This paper uses Monte Carlo simulations to investigate the interaction of short-wave infrared (SWIR) light with vascular tissue as a step toward the development of a non-invasive optical sensor for measuring blood lactate in humans. The primary focus of this work was to determine the optimal source-detector separation, penetration depth of light at SWIR wavelengths in tissue, and the optimal light power required for reliable detection of lactate. The investigation also focused on determining the non-linear variations in absorbance of lactate at a few select SWIR wavelengths. SWIR photons only penetrated 1.3 mm and did not travel beyond the hypodermal fat layer. The maximum output power was only 2.51% of the input power, demonstrating the need for a highly sensitive detection system. Simulations optimized a source-detector separation of 1 mm at 1684 nm for accurate measurement of lactate in blood.
format	article
author	Subhasri Chatterjee Karthik Budidha Meha Qassem Panicos A. Kyriacou
author_facet	Subhasri Chatterjee Karthik Budidha Meha Qassem Panicos A. Kyriacou
author_sort	Subhasri Chatterjee
title	In-silico investigation towards the non-invasive optical detection of blood lactate
title_short	In-silico investigation towards the non-invasive optical detection of blood lactate
title_full	In-silico investigation towards the non-invasive optical detection of blood lactate
title_fullStr	In-silico investigation towards the non-invasive optical detection of blood lactate
title_full_unstemmed	In-silico investigation towards the non-invasive optical detection of blood lactate
title_sort	in-silico investigation towards the non-invasive optical detection of blood lactate
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/68874677331d4baca41dc334bc09d189
work_keys_str_mv	AT subhasrichatterjee insilicoinvestigationtowardsthenoninvasiveopticaldetectionofbloodlactate AT karthikbudidha insilicoinvestigationtowardsthenoninvasiveopticaldetectionofbloodlactate AT mehaqassem insilicoinvestigationtowardsthenoninvasiveopticaldetectionofbloodlactate AT panicosakyriacou insilicoinvestigationtowardsthenoninvasiveopticaldetectionofbloodlactate
_version_	1718384601194299392

In-silico investigation towards the non-invasive optical detection of blood lactate

Ejemplares similares